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Research Article

Epidemiological Pathology of Dementia: Attributable-Risks at Death in the Medical Research Council Cognitive Function and Ageing Study

  • Fiona E. Matthews equal contributor,

    equal contributor Contributed equally to this work with: Fiona E. Matthews, Carol Brayne

    Affiliation: Medical Research Council (MRC) Biostatistics, University of Cambridge, Cambridge, United Kingdom

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  • Carol Brayne equal contributor,

    equal contributor Contributed equally to this work with: Fiona E. Matthews, Carol Brayne

    Affiliation: Institute of Public Health, University of Cambridge, Cambridge, United Kingdom

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  • James Lowe,

    Affiliation: Department of Neuropathology, University of Nottingham, Nottingham, United Kingdom

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  • Ian McKeith,

    Affiliation: Institute for Ageing and Health, University of Newcastle upon Tyne, Newcastle upon Tyne, United Kingdom

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  • Stephen B. Wharton,

    Affiliation: Department of Neuroscience, University of Sheffield, Sheffield, United Kingdom

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  • Paul Ince mail

    p.g.ince@shef.ac.uk

    Affiliation: Department of Neuroscience, University of Sheffield, Sheffield, United Kingdom

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  • Published: November 10, 2009
  • DOI: 10.1371/journal.pmed.1000180

About the Authors

Fiona E. Matthews
Medical Research Council (MRC) Biostatistics, University of Cambridge, Cambridge, United Kingdom
Carol Brayne
Institute of Public Health, University of Cambridge, Cambridge, United Kingdom
James Lowe
Department of Neuropathology, University of Nottingham, Nottingham, United Kingdom
Ian McKeith
Institute for Ageing and Health, University of Newcastle upon Tyne, Newcastle upon Tyne, United Kingdom
Stephen B. Wharton, Paul Ince
Department of Neuroscience, University of Sheffield, Sheffield, United Kingdom

Corresponding Author

Email: p.g.ince@shef.ac.uk

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

ICMJE criteria for authorship read and met: FEM CB JL IM SBW PI. Agree with the manuscript's results and conclusions: FEM CB JL IM SBW PI. Designed the experiments/the study: FEM CB JL IM SBW PI. Analyzed the data: FEM CB JL SBW. Collected data/did experiments for the study: FEM JL SBW PI. Enrolled patients: CB JL. Wrote the first draft of the paper: FEM CB PI. Contributed to the writing of the paper: FEM CB IM SBW. Primary statistical analyses and modeling: FEM. Coordinated the study and supervised the enrollment of respondents: CB PI IM. Pathological validation of cases in series: JL. Neuropathological analysis of cases for the study: SBW.