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Research Article

Potential Role of Decoy B7-H4 in the Pathogenesis of Rheumatoid Arthritis: A Mouse Model Informed by Clinical Data

  • Takeshi Azuma,

    Affiliation: Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America

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  • Gefeng Zhu,

    Affiliation: Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America

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  • Haiying Xu,

    Affiliation: Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America

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  • A. Cecilia Rietz,

    Affiliation: Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America

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  • Charles G. Drake,

    Affiliation: Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America

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  • Eric L. Matteson,

    Affiliation: Division of Rheumatology, Mayo Clinic, Rochester, Minnesota, United States of America

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  • Lieping Chen mail

    lchen42@jhmi.edu

    Affiliation: Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America

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  • Published: October 20, 2009
  • DOI: 10.1371/journal.pmed.1000166

About the Authors

Takeshi Azuma, Gefeng Zhu, Haiying Xu, A. Cecilia Rietz, Charles G. Drake, Lieping Chen
Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
Eric L. Matteson
Division of Rheumatology, Mayo Clinic, Rochester, Minnesota, United States of America

Corresponding Author

Email: lchen42@jhmi.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

ICMJE criteria for authorship read and met: TA GZ HX ACR CD EM LC. Agree with the manuscript's results and conclusions: TA GZ HX ACR CD EM LC. Designed the experiments/the study: TA CD LC. Analyzed the data: TA GZ HX ACR LC. Collected data/did experiments for the study: HX ACR CD LC. Enrolled patients: EM. Wrote the first draft of the paper: TA LC. Contributed to the writing of the paper: TA EM LC.