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Research Article

Cholinesterase Inhibitors and Hospitalization for Bradycardia: A Population-Based Study

  • Laura Y. Park-Wyllie mail,

    parkwylliel@smh.toronto.on.ca

    Affiliations: Department of Family and Community Medicine, St. Michael's Hospital, Toronto, Ontario, Canada, Keenan Research Centre in the Li Ka Shing Knowledge Institute of St. Michael's Hospital, Toronto, Ontario, Canada, Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada

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  • Muhammad M. Mamdani,

    Affiliations: Keenan Research Centre in the Li Ka Shing Knowledge Institute of St. Michael's Hospital, Toronto, Ontario, Canada, Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada, Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Ontario, Canada, Department of Health Policy, Management and Evaluation, University of Toronto, Toronto, Ontario, Canada

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  • Ping Li,

    Affiliation: Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada

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  • Sudeep S. Gill,

    Affiliations: Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada, Department of Medicine at Queens University, Kingston, Ontario, Canada

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  • Andreas Laupacis,

    Affiliations: Keenan Research Centre in the Li Ka Shing Knowledge Institute of St. Michael's Hospital, Toronto, Ontario, Canada, Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada, Department of Health Policy, Management and Evaluation, University of Toronto, Toronto, Ontario, Canada, Department of Medicine, University of Toronto, Toronto, Ontario, Canada

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  • David N. Juurlink

    Affiliations: Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada, Department of Health Policy, Management and Evaluation, University of Toronto, Toronto, Ontario, Canada, Department of Medicine, University of Toronto, Toronto, Ontario, Canada, Department of Medicine, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada

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  • Published: September 29, 2009
  • DOI: 10.1371/journal.pmed.1000157

About the Authors

Laura Y. Park-Wyllie
Department of Family and Community Medicine, St. Michael's Hospital, Toronto, Ontario, Canada
Laura Y. Park-Wyllie, Muhammad M. Mamdani, Andreas Laupacis
Keenan Research Centre in the Li Ka Shing Knowledge Institute of St. Michael's Hospital, Toronto, Ontario, Canada
Laura Y. Park-Wyllie, Muhammad M. Mamdani, Ping Li, Sudeep S. Gill, Andreas Laupacis, David N. Juurlink
Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada
Muhammad M. Mamdani
Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Ontario, Canada
Muhammad M. Mamdani, Andreas Laupacis, David N. Juurlink
Department of Health Policy, Management and Evaluation, University of Toronto, Toronto, Ontario, Canada
Sudeep S. Gill
Department of Medicine at Queens University, Kingston, Ontario, Canada
Andreas Laupacis, David N. Juurlink
Department of Medicine, University of Toronto, Toronto, Ontario, Canada
David N. Juurlink
Department of Medicine, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada

Corresponding Author

Email: parkwylliel@smh.toronto.on.ca

Competing Interests

MMM was employed at Pfizer Global Pharmaceuticals from January 2006 to April 2007.

Author Contributions

ICMJE criteria for authorship read and met: LPW MMM PL SSG AL DNJ. Agree with the manuscript's results and conclusions: LPW MMM PL SSG AL DNJ. Designed the experiments/the study: LPW MMM SSG AL DNJ. Analyzed the data: LPW PL SSG. Wrote the first draft of the paper: LPW. Contributed to the writing of the paper: LPW MMM PL SSG AL DNJ. Helped to design the study, helped to analyze/interpret the data, and contributed to critical revisions of the manuscript: SSG. Supervised LYPW: DNJ.