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Research Article

Effect of Duration and Intermittency of Rifampin on Tuberculosis Treatment Outcomes: A Systematic Review and Meta-Analysis

  • Dick Menzies mail,

    dick.menzies@mcgill.ca

    Affiliation: Respiratory and Epidemiology Clinical Research Unit, Montreal Chest Institute & Department of Epidemiology, Biostatistics & Occupational Health, McGill University, Montreal, Canada

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  • Andrea Benedetti,

    Affiliation: Respiratory and Epidemiology Clinical Research Unit, Montreal Chest Institute & Department of Epidemiology, Biostatistics & Occupational Health, McGill University, Montreal, Canada

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  • Anita Paydar,

    Affiliation: Respiratory and Epidemiology Clinical Research Unit, Montreal Chest Institute & Department of Epidemiology, Biostatistics & Occupational Health, McGill University, Montreal, Canada

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  • Ian Martin,

    Affiliation: Respiratory and Epidemiology Clinical Research Unit, Montreal Chest Institute & Department of Epidemiology, Biostatistics & Occupational Health, McGill University, Montreal, Canada

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  • Sarah Royce,

    Affiliation: University of California at San Francisco, San Francisco, California, United States of America

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  • Madhukar Pai,

    Affiliation: Respiratory and Epidemiology Clinical Research Unit, Montreal Chest Institute & Department of Epidemiology, Biostatistics & Occupational Health, McGill University, Montreal, Canada

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  • Andrew Vernon,

    Affiliation: Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America

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  • Christian Lienhardt,

    Affiliation: International Union against Tuberculosis and Lung Diseases, and Institut de Recherche pour le Développement, Paris, France

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  • William Burman

    Affiliation: Denver Public Health, Denver, Colorado, United States of America

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  • Published: September 15, 2009
  • DOI: 10.1371/journal.pmed.1000146

About the Authors

Dick Menzies, Andrea Benedetti, Anita Paydar, Ian Martin, Madhukar Pai
Respiratory and Epidemiology Clinical Research Unit, Montreal Chest Institute & Department of Epidemiology, Biostatistics & Occupational Health, McGill University, Montreal, Canada
Sarah Royce
University of California at San Francisco, San Francisco, California, United States of America
Andrew Vernon
Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America
Christian Lienhardt
International Union against Tuberculosis and Lung Diseases, and Institut de Recherche pour le Développement, Paris, France
William Burman
Denver Public Health, Denver, Colorado, United States of America

Corresponding Author

Email: dick.menzies@mcgill.ca

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

ICMJE criteria for authorship read and met: DM AB AP IM SR MP AV CL WB. Agree with the manuscript's results and conclusions: DM AB AP IM SR MP AV CL WB. Designed the experiments/the study: DM. Analyzed the data: DM AB. Collected data/did experiments for the study: AP IM WB. Wrote the first draft of the paper: DM. Contributed to the writing of the paper: DM AB AP SR MP AV CL WB. Helped develop statistical analysis plan, helped with interpretation of results: AB. Provided input on systematic review methodology: MP. Participated in critical discussion of the draft initial findings and in revision of the manuscript: AV.