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Research Article

Sleep-Disordered Breathing and Mortality: A Prospective Cohort Study

  • Naresh M. Punjabi mail,

    npunjabi@jhmi.edu

    Affiliation: Johns Hopkins University, Baltimore, Maryland, United States of America

    X
  • Brian S. Caffo,

    Affiliation: Johns Hopkins University, Baltimore, Maryland, United States of America

    X
  • James L. Goodwin,

    Affiliation: University of Arizona, Tucson, Arizona, United States of America

    X
  • Daniel J. Gottlieb,

    Affiliation: VA Boston Healthcare System, Boston, Massachusetts, United States of America

    X
  • Anne B. Newman,

    Affiliation: University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America

    X
  • George T. O'Connor,

    Affiliation: Boston University School of Medicine, Boston, Massachusetts, United States of America

    X
  • David M. Rapoport,

    Affiliation: New York University School of Medicine, New York, New York, United States of America

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  • Susan Redline,

    Affiliation: Case Western Reserve University, Cleveland, Ohio, United States of America

    X
  • Helaine E. Resnick,

    Affiliation: American Association of Homes and Services for the Aging, Washington, D. C., United States of America

    X
  • John A. Robbins,

    Affiliation: University of California, Davis, California, United States of America

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  • Eyal Shahar,

    Affiliation: University of Arizona, Tucson, Arizona, United States of America

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  • Mark L. Unruh,

    Affiliation: University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America

    X
  • Jonathan M. Samet
  • Published: August 18, 2009
  • DOI: 10.1371/journal.pmed.1000132

About the Authors

Naresh M. Punjabi, Brian S. Caffo
Johns Hopkins University, Baltimore, Maryland, United States of America
James L. Goodwin, Eyal Shahar
University of Arizona, Tucson, Arizona, United States of America
Daniel J. Gottlieb
VA Boston Healthcare System, Boston, Massachusetts, United States of America
Anne B. Newman, Mark L. Unruh
University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
George T. O'Connor
Boston University School of Medicine, Boston, Massachusetts, United States of America
David M. Rapoport
New York University School of Medicine, New York, New York, United States of America
Susan Redline
Case Western Reserve University, Cleveland, Ohio, United States of America
Helaine E. Resnick
American Association of Homes and Services for the Aging, Washington, D. C., United States of America
John A. Robbins
University of California, Davis, California, United States of America

Corresponding Author

Email: npunjabi@jhmi.edu

Competing Interests

NMP received honoraria and travel support for continuing medical education lectures or symposia sponsored by Respironics and Resmed Inc. DMR is currently the holder (through New York University) of multiple patents licensed to Covidian and Fisher & Paykel Healthcare on the use of nasal CPAP, the primary treatment of obstructive sleep apnea, and to Advance Brain Monitoring, Protech on diagnostic tools for use in ambulatory monitoring of sleep apnea, and recieves royalties from these. DMR has also held industry-sponsored grants relating to sleep and sleep-disordered breathing treatments with Restore Medical, St. Jude Medical, Guidant (Boston Scientific), Protech, Advanced Brain Monitoring, and Korosensor. At no time were any of the activities of DMR in the Sleep Heart Health Study data collection or analysis directly related to any of his listed activities in ways that compromised the study, as reviewed annually by the Steering Committee. SR has National Institutes of Health grants that fund research into the association of sleep disorders and health outcomes. SR is a member of the Sleep Research Society Board of Directors. SR is the Principal Investigator for a contract between University Hospitals of Cleveland and Dymedix, Inc. to validate sleep signals of sleep apnea diagnosis. MLU has a Baxter Healthcare Grant (Reanalysis of the HEMO Study using novel analytic approaches). MLU is personally unaware of a Baxter sleep product and this support did not influence his contribution to this work.

Author Contributions

ICMJE criteria for authorship read and met: NMP BSC JLG DJG ABN GTO DMR SR HER JR ES MLU JMS. Agree with the manuscript's results and conclusions: NMP BSC JLG DJG ABN GTO DMR SR HER JR ES MLU JMS. Designed the experiments/the study: DJG ABN GTO DMR SR JR ES JMS. Analyzed the data: NMP BSC DJG ABN GTO DMR HER. Collected data/did experiments for the study: NMP JLG DJG ABN GTO DMR SR HER JR ES. Enrolled patients: NMP JLG DJG ABN GTO DMR HER JR. Wrote the first draft of the paper: NMP. Contributed to the writing of the paper: NMP BSC JLG DJG ABN GTO DMR SR HER JR ES MLU JMS. Helped obtain funding: JR. Ran study coordinating center: JMS.