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Research Article

Can Prenatal Malaria Exposure Produce an Immune Tolerant Phenotype?: A Prospective Birth Cohort Study in Kenya

  • Indu Malhotra,

    Affiliation: Center for Global Health and Diseases, Case Western Reserve University, Cleveland, Ohio, United States of America

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  • Arlene Dent,

    Affiliation: Center for Global Health and Diseases, Case Western Reserve University, Cleveland, Ohio, United States of America

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  • Peter Mungai,

    Affiliations: Center for Global Health and Diseases, Case Western Reserve University, Cleveland, Ohio, United States of America, Division of Vector Borne Diseases, Nairobi, Kenya

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  • Alex Wamachi,

    Affiliation: Kenya Medical Research Institute, Nairobi, Kenya

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  • John H. Ouma,

    Affiliation: Division of Vector Borne Diseases, Nairobi, Kenya

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  • David L. Narum,

    Affiliation: Malaria Vaccine Development Unit, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland, United States of America

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  • Eric Muchiri,

    Affiliation: Division of Vector Borne Diseases, Nairobi, Kenya

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  • Daniel J. Tisch,

    Affiliation: Center for Global Health and Diseases, Case Western Reserve University, Cleveland, Ohio, United States of America

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  • Christopher L. King mail

    cxk21@case.edu

    Affiliations: Center for Global Health and Diseases, Case Western Reserve University, Cleveland, Ohio, United States of America, Veterans Affairs Medical Center, Cleveland, Ohio, United States of America

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  • Published: July 28, 2009
  • DOI: 10.1371/journal.pmed.1000116

About the Authors

Indu Malhotra, Arlene Dent, Peter Mungai, Daniel J. Tisch, Christopher L. King
Center for Global Health and Diseases, Case Western Reserve University, Cleveland, Ohio, United States of America
Peter Mungai, John H. Ouma, Eric Muchiri
Division of Vector Borne Diseases, Nairobi, Kenya
Alex Wamachi
Kenya Medical Research Institute, Nairobi, Kenya
David L. Narum
Malaria Vaccine Development Unit, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland, United States of America
Christopher L. King
Veterans Affairs Medical Center, Cleveland, Ohio, United States of America

Corresponding Author

Email: cxk21@case.edu

Competing Interests

David Narum has declared the following competing interest: “Narum et al., United States Patent 7,078,507 for production of recombinant EBA-175 RII protein.”

Author Contributions

ICMJE criteria for authorship read and met: IM AD PM AW JHO DLN EM DJT CLK. Agree with the manuscript's results and conclusions: IM AD PM AW JHO DLN EM DJT CLK. Designed the experiments/the study: IM JHO DJT CLK. Analyzed the data: IM AD JHO CLK. Collected data/did experiments for the study: IM AD DJT CLK. Enrolled patients: PM. Wrote the first draft of the paper: IM CLK. Contributed to the writing of the paper: IM AD AW JHO DLN DJT. Did field co-ordination of the study: PM. Participated in data collection: JHO. Produced and characterized recombinant proteins used in the study: DLM.