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Research Article

Infiltrating Blood-Derived Macrophages Are Vital Cells Playing an Anti-inflammatory Role in Recovery from Spinal Cord Injury in Mice

  • Ravid Shechter equal contributor,

    equal contributor Contributed equally to this work with: Ravid Shechter, Anat London, Chen Varol, Steffen Jung, Michal Schwartz

    Affiliation: Department of Neurobiology, The Weizmann Institute of Science, Rehovot, Israel

    X
  • Anat London equal contributor,

    equal contributor Contributed equally to this work with: Ravid Shechter, Anat London, Chen Varol, Steffen Jung, Michal Schwartz

    Affiliation: Department of Neurobiology, The Weizmann Institute of Science, Rehovot, Israel

    X
  • Chen Varol equal contributor,

    equal contributor Contributed equally to this work with: Ravid Shechter, Anat London, Chen Varol, Steffen Jung, Michal Schwartz

    Affiliation: Department of Immunology, The Weizmann Institute of Science, Rehovot, Israel

    X
  • Catarina Raposo,

    Affiliation: Department of Neurobiology, The Weizmann Institute of Science, Rehovot, Israel

    X
  • Melania Cusimano,

    Affiliation: Neuroimmunology Unit, DIBIT and Institute of Experimental Neurology (INSPE), San Raffaele Scientific Institute, Milan, Italy

    X
  • Gili Yovel,

    Affiliation: Department of Neurobiology, The Weizmann Institute of Science, Rehovot, Israel

    X
  • Asya Rolls,

    Affiliation: Department of Neurobiology, The Weizmann Institute of Science, Rehovot, Israel

    X
  • Matthias Mack,

    Affiliation: Department of Internal Medicine, University of Regensburg, Regensburg, Germany

    X
  • Stefano Pluchino,

    Affiliation: Neuroimmunology Unit, DIBIT and Institute of Experimental Neurology (INSPE), San Raffaele Scientific Institute, Milan, Italy

    X
  • Gianvito Martino,

    Affiliation: Neuroimmunology Unit, DIBIT and Institute of Experimental Neurology (INSPE), San Raffaele Scientific Institute, Milan, Italy

    X
  • Steffen Jung equal contributor mail,

    equal contributor Contributed equally to this work with: Ravid Shechter, Anat London, Chen Varol, Steffen Jung, Michal Schwartz

    s.jung@weizmann.ac.il (SJ); michal.schwartz@weizmann.ac.il (MS)

    Affiliation: Department of Immunology, The Weizmann Institute of Science, Rehovot, Israel

    X
  • Michal Schwartz equal contributor mail

    equal contributor Contributed equally to this work with: Ravid Shechter, Anat London, Chen Varol, Steffen Jung, Michal Schwartz

    s.jung@weizmann.ac.il (SJ); michal.schwartz@weizmann.ac.il (MS)

    Affiliation: Department of Neurobiology, The Weizmann Institute of Science, Rehovot, Israel

    X
  • Published: July 28, 2009
  • DOI: 10.1371/journal.pmed.1000113

About the Authors

Ravid Shechter, Anat London, Catarina Raposo, Gili Yovel, Asya Rolls, Michal Schwartz
Department of Neurobiology, The Weizmann Institute of Science, Rehovot, Israel
Chen Varol, Steffen Jung
Department of Immunology, The Weizmann Institute of Science, Rehovot, Israel
Melania Cusimano, Stefano Pluchino, Gianvito Martino
Neuroimmunology Unit, DIBIT and Institute of Experimental Neurology (INSPE), San Raffaele Scientific Institute, Milan, Italy
Matthias Mack
Department of Internal Medicine, University of Regensburg, Regensburg, Germany

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

ICMJE criteria for authorship read and met: RS AL CV CR MC GY AR MM SP GM SJ MS. Agree with the manuscript's results and conclusions: RS AL CV CR MC GY AR MM SP GM SJ MS. Designed the experiments/the study: RS AL CV MM SJ MS. Analyzed the data: RS AL CV CR MC. Collected data/did experiments for the study: RS AL CV GY SJ. Wrote the first draft of the paper: RS AL CV MS. Contributed to the writing of the paper: RS AL CV MM SP SJ MS. Immunohistochemistry: CR. Collaborated on the in vivo experiments and in vitro immunohistochemistry: MC. Contributed to the design of the experiments with antibody-mediated depletion of monocytes: MM. Contributed to the design of the study: GM.