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The PRISMA Statement for Reporting Systematic Reviews and Meta-Analyses of Studies That Evaluate Health Care Interventions: Explanation and Elaboration

  • Alessandro Liberati mail,

    alesslib@mailbase.it

    Affiliations: Università di Modena e Reggio Emilia, Modena, Italy, Centro Cochrane Italiano, Istituto Ricerche Farmacologiche Mario Negri, Milan, Italy

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  • Douglas G. Altman,

    Affiliation: Centre for Statistics in Medicine, University of Oxford, Oxford, United Kingdom

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  • Jennifer Tetzlaff,

    Affiliation: Ottawa Methods Centre, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada

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  • Cynthia Mulrow,

    Affiliation: Annals of Internal Medicine, Philadelphia, Pennsylvania, United States of America

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  • Peter C. Gøtzsche,

    Affiliation: The Nordic Cochrane Centre, Copenhagen, Denmark

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  • John P. A. Ioannidis,

    Affiliation: Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece

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  • Mike Clarke,

    Affiliations: UK Cochrane Centre, Oxford, United Kingdom, School of Nursing and Midwifery, Trinity College, Dublin, Ireland

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  • P. J. Devereaux,

    Affiliation: Departments of Medicine, Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada

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  • Jos Kleijnen,

    Affiliations: Kleijnen Systematic Reviews Ltd, York, United Kingdom, School for Public Health and Primary Care (CAPHRI), University of Maastricht, Maastricht, The Netherlands

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  • David Moher

    Affiliations: Ottawa Methods Centre, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada, Department of Epidemiology and Community Medicine, Faculty of Medicine, Ottawa, Ontario, Canada

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  • Published: July 21, 2009
  • DOI: 10.1371/journal.pmed.1000100

About the Authors

Alessandro Liberati
Università di Modena e Reggio Emilia, Modena, Italy
Alessandro Liberati
Centro Cochrane Italiano, Istituto Ricerche Farmacologiche Mario Negri, Milan, Italy
Douglas G. Altman
Centre for Statistics in Medicine, University of Oxford, Oxford, United Kingdom
Jennifer Tetzlaff, David Moher
Ottawa Methods Centre, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada
Cynthia Mulrow
Annals of Internal Medicine, Philadelphia, Pennsylvania, United States of America
Peter C. Gøtzsche
The Nordic Cochrane Centre, Copenhagen, Denmark
John P. A. Ioannidis
Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece
Mike Clarke
UK Cochrane Centre, Oxford, United Kingdom
Mike Clarke
School of Nursing and Midwifery, Trinity College, Dublin, Ireland
P. J. Devereaux
Departments of Medicine, Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada
Jos Kleijnen
Kleijnen Systematic Reviews Ltd, York, United Kingdom
Jos Kleijnen
School for Public Health and Primary Care (CAPHRI), University of Maastricht, Maastricht, The Netherlands
David Moher
Department of Epidemiology and Community Medicine, Faculty of Medicine, Ottawa, Ontario, Canada

Corresponding Author

Email: alesslib@mailbase.it

Competing Interests

MC's employment is as Director of the UK Cochrane Centre. He is employed by the Oxford Radcliffe Hospitals Trust on behalf of the Department of Health and the National Institute for Health Research in England. This is a fixed term contract, the renewal of which is dependent upon the value placed upon his work, that of the UK Cochrane Centre, and of The Cochrane Collaboration more widely by the Department of Health. His work involves the conduct of systematic reviews and the support of the conduct and use of systematic reviews. Therefore, work–such as this manuscript–relating to systematic reviews might have an impact on his employment.

Author Contributions

ICMJE criteria for authorship read and met: AL DGA JT CM PCG JPAI MC PJD JK DM. Wrote the first draft of the paper: AL DGA JT JPAI DM. Contributed to the writing of the paper: AL DGA JT CM PCG JPAI MC PJD JK DM. Concept and design of the Explanation and Elaboration statement: AL DGA JT DM. Agree with the recommendations: AL DGA JT CM PCG JPAI MC PJD JK DM.