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Research Article

Functional Substitution by TAT-Utrophin in Dystrophin-Deficient Mice

  • Kevin J. Sonnemann,

    Affiliation: Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, Minnesota, United States of America

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  • Hanke Heun-Johnson,

    Affiliation: Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, Minnesota, United States of America

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  • Amy J. Turner,

    Affiliation: Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, Minnesota, United States of America

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  • Kristen A. Baltgalvis,

    Affiliation: Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, Minnesota, United States of America

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  • Dawn A. Lowe,

    Affiliation: Program in Physical Therapy, University of Minnesota, Minneapolis, Minnesota, United States of America

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  • James M. Ervasti mail

    jervasti@umn.edu

    Affiliation: Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, Minnesota, United States of America

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  • Published: May 26, 2009
  • DOI: 10.1371/journal.pmed.1000083

About the Authors

Kevin J. Sonnemann, Hanke Heun-Johnson, Amy J. Turner, Kristen A. Baltgalvis, James M. Ervasti
Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, Minnesota, United States of America
Dawn A. Lowe
Program in Physical Therapy, University of Minnesota, Minneapolis, Minnesota, United States of America

Corresponding Author

Email: jervasti@umn.edu

Competing Interests

KJS and JME are co-inventors on a patent application filed on TAT-utrophin.

Author Contributions

ICMJE criteria for authorship read and met: KJS HHJ AJT KAB DAL JME. Agree with the manuscript's results and conclusions: KJS HHJ AJT KAB DAL JME. Designed the experiments/the study: KJS DAL JME. Analyzed the data: KJS HHJ AJT KAB JME. Collected data/did experiments for the study: KJS HHJ AJT KAB. Wrote the first draft of the paper: KJS. Contributed to the writing of the paper: KJS HHJ AJT DAL JME. DNA cloning, protein expression, protein purification, SDS-PAGE, Western blotting, actin binding assay: HHJ. Purified protein, injected animals, SDS-PAGE, IF, BN native gels, immunohistochemisty: AJT. Collected the physiology data: KAB. Designed the physiological analyses: DAL.