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Research Article

Suppression of GATA-3 Nuclear Import and Phosphorylation: A Novel Mechanism of Corticosteroid Action in Allergic Disease

  • Kittipong Maneechotesuwan,

    Affiliation: Airway Disease Section, National Heart and Lung Institute, Imperial College, London, United Kingdom

    Current address: Division of Respiratory Disease and Tuberculosis, Department of Internal Medicine, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand.

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  • Xin Yao,

    Affiliation: Airway Disease Section, National Heart and Lung Institute, Imperial College, London, United Kingdom

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  • Kazuhiro Ito,

    Affiliation: Airway Disease Section, National Heart and Lung Institute, Imperial College, London, United Kingdom

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  • Elen Jazrawi,

    Affiliation: Airway Disease Section, National Heart and Lung Institute, Imperial College, London, United Kingdom

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  • Omar S. Usmani,

    Affiliation: Airway Disease Section, National Heart and Lung Institute, Imperial College, London, United Kingdom

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  • Ian M. Adcock,

    Affiliation: Airway Disease Section, National Heart and Lung Institute, Imperial College, London, United Kingdom

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  • Peter J. Barnes mail

    p.j.barnes@imperial.ac.uk

    Affiliation: Airway Disease Section, National Heart and Lung Institute, Imperial College, London, United Kingdom

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  • Published: May 19, 2009
  • DOI: 10.1371/journal.pmed.1000076

About the Authors

Kittipong Maneechotesuwan, Xin Yao, Kazuhiro Ito, Elen Jazrawi, Omar S. Usmani, Ian M. Adcock, Peter J. Barnes
Airway Disease Section, National Heart and Lung Institute, Imperial College, London, United Kingdom

Corresponding Author

Email: p.j.barnes@imperial.ac.uk

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

ICMJE criteria for authorship read and met: KM XY KI EJ OSU IMA PJB. Agree with the manuscript's results and conclusions: KM XY KI EJ OSU IMA PJB. Designed the experiments/the study: KM KI IMA PJB. Analyzed the data: KM XY KI EJ OSU PJB. Collected data/did experiments for the study: KM KI PJB. Enrolled patients: KM OSU PJB. Wrote the first draft of the paper: PJB. Contributed to the writing of the paper: KI IMA PJB. Originated hypothesis and did in vitro, ex vivo, and in vivo experiments: KM. Did some experiments for the study: XY. Contributed to setting up some of evaluating systems, designed and analyzed some experiments: KI.