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In Global Health Research, Is It Legitimate To Stop Clinical Trials Early on Account of Their Opportunity Costs?

  • James V. Lavery mail,

    jim.lavery@utoronto.ca (JVL); buchanan@schoolph.umass.edu (DB)

    Affiliations: Centre for Research on Inner City Health and Centre for Global Health Research, The Keenan Research Centre in the Li Ka Shing Knowledge Institute of St. Michael's Hospital, Toronto, Ontario, Canada, Dalla Lana School of Public Health and Joint Centre for Bioethics, University of Toronto, Toronto, Ontario, Canada, McLaughlin-Rotman Centre for Global Health, University Health Network and University of Toronto, Toronto, Ontario, Canada

    X
  • Peter A. Singer,

    Affiliation: McLaughlin-Rotman Centre for Global Health, University Health Network and University of Toronto, Toronto, Ontario, Canada

    X
  • Renee Ridzon,

    Affiliation: HIV, TB & Reproductive Health Program, Bill & Melinda Gates Foundation, Seattle, Washington, United States of America

    X
  • Jerome A. Singh,

    Affiliations: Dalla Lana School of Public Health and Joint Centre for Bioethics, University of Toronto, Toronto, Ontario, Canada, McLaughlin-Rotman Centre for Global Health, University Health Network and University of Toronto, Toronto, Ontario, Canada, Centre for the AIDS Programme of Research in South Africa (CAPRISA), Durban, KwaZulu-Natal, South Africa

    X
  • Arthur S. Slutsky,

    Affiliations: Departments of Medicine and Critical Care, and The Keenan Research Centre in the Li Ka Shing Knowledge2 Institute of St. Michael's Hospital, Toronto, Ontario, Canada, Departments of Medicine, Surgery and Biomedical Engineering, University of Toronto, Toronto, Ontario, Canada

    X
  • Joseph J. Anisko,

    Affiliation: Independent Consultant, West Chester, Pennsylvania, United States of America

    X
  • David Buchanan mail

    jim.lavery@utoronto.ca (JVL); buchanan@schoolph.umass.edu (DB)

    Affiliation: School of Public Health and Health Sciences, University of Massachusetts, Amherst, Massachusetts, United States of America

    X
  • Published: June 09, 2009
  • DOI: 10.1371/journal.pmed.1000071

About the Authors

James V. Lavery
Centre for Research on Inner City Health and Centre for Global Health Research, The Keenan Research Centre in the Li Ka Shing Knowledge Institute of St. Michael's Hospital, Toronto, Ontario, Canada
James V. Lavery, Jerome A. Singh
Dalla Lana School of Public Health and Joint Centre for Bioethics, University of Toronto, Toronto, Ontario, Canada
James V. Lavery, Peter A. Singer, Jerome A. Singh
McLaughlin-Rotman Centre for Global Health, University Health Network and University of Toronto, Toronto, Ontario, Canada
Renee Ridzon
HIV, TB & Reproductive Health Program, Bill & Melinda Gates Foundation, Seattle, Washington, United States of America
Jerome A. Singh
Centre for the AIDS Programme of Research in South Africa (CAPRISA), Durban, KwaZulu-Natal, South Africa
Arthur S. Slutsky
Departments of Medicine and Critical Care, and The Keenan Research Centre in the Li Ka Shing Knowledge2 Institute of St. Michael's Hospital, Toronto, Ontario, Canada
Arthur S. Slutsky
Departments of Medicine, Surgery and Biomedical Engineering, University of Toronto, Toronto, Ontario, Canada
Joseph J. Anisko
Independent Consultant, West Chester, Pennsylvania, United States of America
David Buchanan
School of Public Health and Health Sciences, University of Massachusetts, Amherst, Massachusetts, United States of America

Corresponding Authors

Competing Interests

Renee Ridzon is a senior scientific program officer with the Bill & Melinda Gates Foundation. Jocalyn Clark provided helpful comments on an earlier version of this manuscript in her capacity as a colleague at the University of Toronto. She was not involved in the editorial decision-making process for this paper at PLoS Medicine.

Author Contributions

ICMJE criteria for authorship read and met: JVL PAS RR JAS ASS JJA DB. Contributed to the writing of the paper: JVL PAS RR JAS ASS JJA DB.