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Research Article

Preconceptional Folate Supplementation and the Risk of Spontaneous Preterm Birth: A Cohort Study

  • Radek Bukowski mail,

    rkbukows@utmb.edu

    Affiliation: University of Texas Medical Branch, Department of Obstetrics and Gynecology, Galveston, Texas, United States of America

    X
  • Fergal D. Malone,

    Affiliation: Royal College of Surgeons in Ireland, Department of Obstetrics and Gynecology, Dublin, Ireland

    X
  • Flint T. Porter,

    Affiliation: University of Utah, Salt Lake City, Utah, United States of America

    X
  • David A. Nyberg,

    Affiliation: The Fetal & Women's Center of Arizona, Scottsdale, Arizona, United States of America

    X
  • Christine H. Comstock,

    Affiliation: William Beaumont Hospital, Fetal Imaging Department, Royal Oak, Michigan, United States of America

    X
  • Gary D. V. Hankins,

    Affiliation: University of Texas Medical Branch, Department of Obstetrics and Gynecology, Galveston, Texas, United States of America

    X
  • Keith Eddleman,

    Affiliation: Mount Sinai Medical Center, Department of Obstetrics and Gynecology, New York, New York, United States of America

    X
  • Susan J. Gross,

    Affiliation: Montefiore Medical Center–Albert Einstein College of Medicine, Department of Obstetrics & Gynecology and Women's Health, Bronx, New York, United States of America

    X
  • Lorraine Dugoff,

    Affiliation: University of Colorado Health Sciences Center, Department of Obstetrics and Gynecology, Denver, Colorado, United States of America

    X
  • Sabrina D. Craigo,

    Affiliation: Tufts-New England Medical Center, Department of Obstetrics and Gynecology, Boston, Massachusetts, United States of America

    X
  • Ilan E. Timor-Tritsch,

    Affiliation: New York University Medical Center, School of Medicine, Department of Obstetrics and Gynecology, New York, New York, United States of America

    X
  • Stephen R. Carr,

    Affiliation: Brown University/Women & Infants' Hospital, Department of Obstetrics and Gynecology, Providence, Rhode Island, United States of America

    X
  • Honor M. Wolfe,

    Affiliation: University of North Carolina at Chapel Hill, Department of Obstetrics and Gynecology, Chapel Hill, North Carolina, United States of America

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  • Mary E. D'Alton

    Affiliation: Columbia University Medical Center, Department of Obstetrics and Gynecology, Maternal-Fetal Medicine, New York, New York, United States of America

    X
  • Published: May 12, 2009
  • DOI: 10.1371/journal.pmed.1000061
  • Featured in PLOS Collections

About the Authors

Radek Bukowski, Gary D. V. Hankins
University of Texas Medical Branch, Department of Obstetrics and Gynecology, Galveston, Texas, United States of America
Fergal D. Malone
Royal College of Surgeons in Ireland, Department of Obstetrics and Gynecology, Dublin, Ireland
Flint T. Porter
University of Utah, Salt Lake City, Utah, United States of America
David A. Nyberg
The Fetal & Women's Center of Arizona, Scottsdale, Arizona, United States of America
Christine H. Comstock
William Beaumont Hospital, Fetal Imaging Department, Royal Oak, Michigan, United States of America
Keith Eddleman
Mount Sinai Medical Center, Department of Obstetrics and Gynecology, New York, New York, United States of America
Susan J. Gross
Montefiore Medical Center–Albert Einstein College of Medicine, Department of Obstetrics & Gynecology and Women's Health, Bronx, New York, United States of America
Lorraine Dugoff
University of Colorado Health Sciences Center, Department of Obstetrics and Gynecology, Denver, Colorado, United States of America
Sabrina D. Craigo
Tufts-New England Medical Center, Department of Obstetrics and Gynecology, Boston, Massachusetts, United States of America
Ilan E. Timor-Tritsch
New York University Medical Center, School of Medicine, Department of Obstetrics and Gynecology, New York, New York, United States of America
Stephen R. Carr
Brown University/Women & Infants' Hospital, Department of Obstetrics and Gynecology, Providence, Rhode Island, United States of America
Honor M. Wolfe
University of North Carolina at Chapel Hill, Department of Obstetrics and Gynecology, Chapel Hill, North Carolina, United States of America
Mary E. D'Alton
Columbia University Medical Center, Department of Obstetrics and Gynecology, Maternal-Fetal Medicine, New York, New York, United States of America

Corresponding Author

Email: rkbukows@utmb.edu

Competing Interests

Mary D'Alton has acted as a consultant for Artemis Health.

Author Contributions

ICMJE criteria for authorship read and met: RB FDM FTP DAN CHC GDVH KE SJG LD SDC IETT SRC HMW MED. Agree with the manuscript's results and conclusions: RB FDM FTP DAN CHC GDVH KE SJG LD SDC IETT SRC HMW MED. Designed the experiments/the study: RB FDM GDVH KE. Analyzed the data: RB FDM CHC GDVH KE SJG LD SDC SRC HMW. Collected data/did experiments for the study: RB. Enrolled patients: RB FDM FTP DAN CHC GDVH KE LD SDC IETT SRC HMW. Wrote the first draft of the paper: RB. Contributed to the writing of the paper: RB FDM DAN CHC GDVH SJG LD SDC SRC HMW. Collected data on 3,000 of the patients: CC. A site PI for FASTER study: SJG. Enrolled patients, collected data, and contributed to study design in the original trial: SDC SRC. Was one of the site PIs for this study: SC.