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Research Article

A Novel Diagnostic Target in the Hepatitis C Virus Genome

  • Jan Felix Drexler,

    Affiliations: Clinical Virology Group, Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany, Institute of Virology, University of Bonn, Bonn, Germany, Infectious Diseases Research Laboratory, University Hospital Prof. Edgard Santos, Federal University of Bahia, Salvador, Brazil

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  • Bernd Kupfer,

    Affiliation: Institute of Virology, University of Bonn, Bonn, Germany

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  • Nadine Petersen,

    Affiliation: Clinical Virology Group, Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany

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  • Rejane Maria Tommasini Grotto,

    Affiliation: University of São Paulo State (UNESP), Botucatu Medical School, Blood Transfusion Centre - Molecular Biology Laboratory and Internal Medicine Department, Botucatu, São Paulo, Brazil

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  • Silvia Maria Corvino Rodrigues,

    Affiliation: University of São Paulo State (UNESP), Botucatu Medical School, Blood Transfusion Centre - Molecular Biology Laboratory and Internal Medicine Department, Botucatu, São Paulo, Brazil

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  • Klaus Grywna,

    Affiliation: Clinical Virology Group, Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany

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  • Marcus Panning,

    Affiliation: Clinical Virology Group, Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany

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  • Augustina Annan,

    Affiliation: Clinical Virology Group, Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany

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  • Giovanni Faria Silva,

    Affiliation: University of São Paulo State (UNESP), Botucatu Medical School, Blood Transfusion Centre - Molecular Biology Laboratory and Internal Medicine Department, Botucatu, São Paulo, Brazil

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  • Jill Douglas,

    Affiliation: Virus Evolution Group, Centre for Infectious Diseases, University of Edinburgh, Edinburgh, United Kingdom

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  • Evelyn S. C Koay,

    Affiliations: Department of Pathology, Yong Loo Lin School of Medicine, National University of Singapore, Molecular Diagnosis Centre, National University Hospital, Singapore

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  • Heidi Smuts,

    Affiliation: Division Medical Virology/National Health Laboratory Service, Department of Clinical Laboratory Sciences, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa

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  • Eduardo M Netto,

    Affiliation: Infectious Diseases Research Laboratory, University Hospital Prof. Edgard Santos, Federal University of Bahia, Salvador, Brazil

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  • Peter Simmonds,

    Affiliation: Virus Evolution Group, Centre for Infectious Diseases, University of Edinburgh, Edinburgh, United Kingdom

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  • Maria Inês de Moura Campos Pardini,

    Affiliation: University of São Paulo State (UNESP), Botucatu Medical School, Blood Transfusion Centre - Molecular Biology Laboratory and Internal Medicine Department, Botucatu, São Paulo, Brazil

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  • W. Kurt Roth,

    Affiliation: GFE Blut mbH, Frankfurt (Main), Germany

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  • Christian Drosten mail

    To whom correspondence should be addressed. E-mail: drosten@virology-bonn.de

    Affiliation: Institute of Virology, University of Bonn, Bonn, Germany

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  • Published: February 10, 2009
  • DOI: 10.1371/journal.pmed.1000031

About the Authors

Jan Felix Drexler, Nadine Petersen, Klaus Grywna, Marcus Panning, Augustina Annan
Clinical Virology Group, Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany
Jan Felix Drexler, Bernd Kupfer, Christian Drosten
Institute of Virology, University of Bonn, Bonn, Germany
Jan Felix Drexler, Eduardo M Netto
Infectious Diseases Research Laboratory, University Hospital Prof. Edgard Santos, Federal University of Bahia, Salvador, Brazil
Rejane Maria Tommasini Grotto, Silvia Maria Corvino Rodrigues, Giovanni Faria Silva, Maria Inês de Moura Campos Pardini
University of São Paulo State (UNESP), Botucatu Medical School, Blood Transfusion Centre - Molecular Biology Laboratory and Internal Medicine Department, Botucatu, São Paulo, Brazil
Jill Douglas, Peter Simmonds
Virus Evolution Group, Centre for Infectious Diseases, University of Edinburgh, Edinburgh, United Kingdom
Evelyn S. C Koay
Department of Pathology, Yong Loo Lin School of Medicine, National University of Singapore
Evelyn S. C Koay
Molecular Diagnosis Centre, National University Hospital, Singapore
Heidi Smuts
Division Medical Virology/National Health Laboratory Service, Department of Clinical Laboratory Sciences, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa
W. Kurt Roth
GFE Blut mbH, Frankfurt (Main), Germany

Corresponding Author

Email: drosten@virology-bonn.de

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

JFD and CD conceived and designed the experiments. JFD, BK, NP, RMTG, SMCR, KG, MP, AA, GFS, JD, ESCK, HS, PS, MIdMCP, and WKR performed the experiments. JFD, EMN, and CD analyzed the data. BK, RMTG, SMCR, GFS, JD, ESCK, HS, PS, MIdMCP, and WKR contributed materials. JFD and CD wrote the paper.