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Research Article

Donor-Derived Brain Tumor Following Neural Stem Cell Transplantation in an Ataxia Telangiectasia Patient

  • Ninette Amariglio,

    Affiliations: Cancer Research Center, Sheba Medical Center and Sackler School of Medicine, Tel Aviv University, Tel-Aviv, Israel, Institute of Hematology, Sheba Medical Center, Tel Hashomer, Israel

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  • Abraham Hirshberg,

    Affiliation: Department of Oral Pathology, School of Dental Medicine, Tel Aviv University, Tel-Aviv, Israel

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  • Bernd W Scheithauer,

    Affiliation: Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, United States of America

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  • Yoram Cohen,

    Affiliation: Cancer Research Center, Sheba Medical Center and Sackler School of Medicine, Tel Aviv University, Tel-Aviv, Israel

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  • Ron Loewenthal,

    Affiliation: Tissue Typing Laboratory, Sheba Medical Center and Sackler School of Medicine, Tel Aviv University, Tel-Aviv, Israel

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  • Luba Trakhtenbrot,

    Affiliation: Institute of Hematology, Sheba Medical Center, Tel Hashomer, Israel

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  • Nurit Paz,

    Affiliation: Cancer Research Center, Sheba Medical Center and Sackler School of Medicine, Tel Aviv University, Tel-Aviv, Israel

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  • Maya Koren-Michowitz,

    Affiliation: Institute of Hematology, Sheba Medical Center, Tel Hashomer, Israel

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  • Dalia Waldman,

    Affiliation: Department of Pediatric Hemato-Oncology, Sheba Medical Center and Sackler School of Medicine, Tel Aviv University, Tel-Aviv, Israel

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  • Leonor Leider-Trejo,

    Affiliation: Institute of Pathology, Tel-Aviv Medical Center, Tel-Aviv, Israel

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  • Amos Toren,

    Affiliation: Department of Pediatric Hemato-Oncology, Sheba Medical Center and Sackler School of Medicine, Tel Aviv University, Tel-Aviv, Israel

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  • Shlomi Constantini,

    Affiliation: Pediatric Neurosurgery, Dana Children's Hospital, Tel-Aviv Medical Center, and Sackler School of Medicine, Tel Aviv University, Tel-Aviv, Israel

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  • Gideon Rechavi mail

    To whom correspondence should be addressed. E-mail: gidi.rechavi@sheba.health.gov.il

    Affiliations: Cancer Research Center, Sheba Medical Center and Sackler School of Medicine, Tel Aviv University, Tel-Aviv, Israel, Department of Pediatric Hemato-Oncology, Sheba Medical Center and Sackler School of Medicine, Tel Aviv University, Tel-Aviv, Israel

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  • Published: February 17, 2009
  • DOI: 10.1371/journal.pmed.1000029

About the Authors

Ninette Amariglio, Yoram Cohen, Nurit Paz, Gideon Rechavi
Cancer Research Center, Sheba Medical Center and Sackler School of Medicine, Tel Aviv University, Tel-Aviv, Israel
Ninette Amariglio, Luba Trakhtenbrot, Maya Koren-Michowitz
Institute of Hematology, Sheba Medical Center, Tel Hashomer, Israel
Abraham Hirshberg
Department of Oral Pathology, School of Dental Medicine, Tel Aviv University, Tel-Aviv, Israel
Bernd W Scheithauer
Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, United States of America
Ron Loewenthal
Tissue Typing Laboratory, Sheba Medical Center and Sackler School of Medicine, Tel Aviv University, Tel-Aviv, Israel
Dalia Waldman, Amos Toren, Gideon Rechavi
Department of Pediatric Hemato-Oncology, Sheba Medical Center and Sackler School of Medicine, Tel Aviv University, Tel-Aviv, Israel
Leonor Leider-Trejo
Institute of Pathology, Tel-Aviv Medical Center, Tel-Aviv, Israel
Shlomi Constantini
Pediatric Neurosurgery, Dana Children's Hospital, Tel-Aviv Medical Center, and Sackler School of Medicine, Tel Aviv University, Tel-Aviv, Israel

Corresponding Author

Email: gidi.rechavi@sheba.health.gov.il

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

NA, RL, SC, and GR designed the experiments/the study. NA, AH, BWS, YC, LT, NP, DW, AT, and SC collected data or did experiments for the study. NA, AH, YC, RL, LT, NP, MK-M, DW, LL-T, AT, SC, and GR analyzed the data. NA, AH, BWS, RL, LT, MK-M, LL-T, AT, SC, and GR contributed to writing the paper.