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Research Article

Reduced Glomerular Filtration Rate and Its Association with Clinical Outcome in Older Patients at Risk of Vascular Events: Secondary Analysis

  • Ian Ford mail,

    To whom correspondence should be addressed. E-mail: ian@stats.gla.ac.uk

    Affiliation: Robertson Centre for Biostatistics, University of Glasgow, Glasgow, Scotland

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  • Vladimir Bezlyak,

    Affiliation: Robertson Centre for Biostatistics, University of Glasgow, Glasgow, Scotland

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  • David J Stott,

    Affiliation: Academic Section of Geriatric Medicine, Cardiovascular Division, University of Glasgow, Glasgow, Scotland

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  • Naveed Sattar,

    Affiliation: Department of Vascular Biochemistry, North Glasgow Division, Greater Glasgow Health Board, Glasgow, Scotland

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  • Chris J Packard,

    Affiliation: Department of Vascular Biochemistry, North Glasgow Division, Greater Glasgow Health Board, Glasgow, Scotland

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  • Ivan Perry,

    Affiliation: Department of Pharmacology and Therapeutics, Cork University Hospital, Wilton, Cork, Ireland

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  • Brendan M Buckley,

    Affiliation: Department of Pharmacology and Therapeutics, Cork University Hospital, Wilton, Cork, Ireland

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  • J. Wouter Jukema,

    Affiliation: Department of Cardiology, Leiden University Medical Centre, Leiden, The Netherlands

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  • Anton J. M de Craen,

    Affiliation: Section of Gerontology and Geriatrics, Leiden University Medical Centre, Leiden, The Netherlands

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  • Rudi G. J Westendorp,

    Affiliation: Section of Gerontology and Geriatrics, Leiden University Medical Centre, Leiden, The Netherlands

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  • James Shepherd

    Affiliation: Department of Vascular Biochemistry, North Glasgow Division, Greater Glasgow Health Board, Glasgow, Scotland

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  • Published: January 20, 2009
  • DOI: 10.1371/journal.pmed.1000016

About the Authors

Ian Ford, Vladimir Bezlyak
Robertson Centre for Biostatistics, University of Glasgow, Glasgow, Scotland
David J Stott
Academic Section of Geriatric Medicine, Cardiovascular Division, University of Glasgow, Glasgow, Scotland
Naveed Sattar, Chris J Packard, James Shepherd
Department of Vascular Biochemistry, North Glasgow Division, Greater Glasgow Health Board, Glasgow, Scotland
Ivan Perry, Brendan M Buckley
Department of Pharmacology and Therapeutics, Cork University Hospital, Wilton, Cork, Ireland
J. Wouter Jukema
Department of Cardiology, Leiden University Medical Centre, Leiden, The Netherlands
Anton J. M de Craen, Rudi G. J Westendorp
Section of Gerontology and Geriatrics, Leiden University Medical Centre, Leiden, The Netherlands

Corresponding Author

Email: ian@stats.gla.ac.uk

Competing Interests

JS reports that he was a consultant to Pfizer in the Treating to New Targets study and that he has been a speaker's bureau member for AstraZeneca and Pfizer.

Author Contributions

IF, DJS, CJP, IP, BMB, JWJ, AJMdC, RGJW, and JS designed the study. IF, VB, NS, BMB, JWJ, RGJW, and JS analyzed the data. BMB, JWJ, RGJW, and JS enrolled patients. IF, VB, DJS, NS, CJP, IP, BMB, JWJ, AJMdC, RGJW, and JS contributed to writing the paper.