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Research Article

Stress-Mediated Increases in Systemic and Local Epinephrine Impair Skin Wound Healing: Potential New Indication for Beta Blockers

  • Raja K Sivamani,

    Affiliation: Department of Dermatology, University of California, Davis, School of Medicine, Davis, California, United States of America

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  • Christine E Pullar,

    Affiliation: Department of Dermatology, University of California, Davis, School of Medicine, Davis, California, United States of America

    ¤ Current address: Department of Cell Physiology and Pharmacology, University of Leicester, United Kingdom

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  • Catherine G Manabat-Hidalgo,

    Affiliation: Department of Dermatology, University of California, Davis, School of Medicine, Davis, California, United States of America

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  • David M Rocke,

    Affiliation: Division of Biostatistics, University of California, Davis, School of Medicine, Davis, California, United States of America

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  • Richard C Carlsen,

    Affiliation: Department of Physiology and Membrane Biology, University of California, Davis, School of Medicine, Davis, California, United States of America

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  • David G Greenhalgh,

    Affiliations: Department of Surgery, University of California, Davis, School of Medicine, Davis, California, United States of America, Shriners Hospitals for Children Northern California, Sacramento, California, United States of America

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  • R. Rivkah Isseroff mail

    To whom correspondence should be addressed. E-mail: rrisseroff@ucdavis.edu

    Affiliations: Department of Dermatology, University of California, Davis, School of Medicine, Davis, California, United States of America, Shriners Hospitals for Children Northern California, Sacramento, California, United States of America, Wound Service, Department of Veterans Affairs, Northern California Health Care System, Mather, California, United States of America

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  • Published: January 13, 2009
  • DOI: 10.1371/journal.pmed.1000012

About the Authors

Raja K Sivamani, Christine E Pullar, Catherine G Manabat-Hidalgo, R. Rivkah Isseroff
Department of Dermatology, University of California, Davis, School of Medicine, Davis, California, United States of America
David M Rocke
Division of Biostatistics, University of California, Davis, School of Medicine, Davis, California, United States of America
Richard C Carlsen
Department of Physiology and Membrane Biology, University of California, Davis, School of Medicine, Davis, California, United States of America
David G Greenhalgh
Department of Surgery, University of California, Davis, School of Medicine, Davis, California, United States of America
David G Greenhalgh, R. Rivkah Isseroff
Shriners Hospitals for Children Northern California, Sacramento, California, United States of America
R. Rivkah Isseroff
Wound Service, Department of Veterans Affairs, Northern California Health Care System, Mather, California, United States of America

Corresponding Author

Email: rrisseroff@ucdavis.edu

Competing Interests

RRI and CEP are named in a patent application submitted by the University of California for the use of beta adrenergic agents in modulating wound repair.

Author Contributions

RKS, CEP, CGM-H, DGG, and RRI contributed to the design of the experiments. RCC and DGG provided oversight on the murine burn wound protocols. RKS and CGM-H conducted all of the experiments and RKS, CEP, CGM-H, DGG, and RRI participated in data analysis and interpretation. DMR conducted the statistical analysis. RKS, CGM-H, and RRI participated in writing this report, and RRI critically edited the manuscript. All authors have read and approved the final version.