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Research Article

A Randomised Controlled Trial of Artemether-Lumefantrine Versus Artesunate for Uncomplicated Plasmodium falciparum Treatment in Pregnancy

  • Rose McGready mail,

    To whom correspondence should be addressed. E-mail: rose@shoklo-unit.com

    Affiliations: Shoklo Malaria Research Unit (SMRU), Mae Sot, Tak, Thailand, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand, Centre for Clinical Vaccinology and Tropical Medicine, Churchill Hospital, Oxford, United Kingdom

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  • Saw Oo Tan,

    Affiliation: Shoklo Malaria Research Unit (SMRU), Mae Sot, Tak, Thailand

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  • Elizabeth A Ashley,

    Affiliations: Shoklo Malaria Research Unit (SMRU), Mae Sot, Tak, Thailand, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand, Centre for Clinical Vaccinology and Tropical Medicine, Churchill Hospital, Oxford, United Kingdom

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  • Mupawjay Pimanpanarak,

    Affiliation: Shoklo Malaria Research Unit (SMRU), Mae Sot, Tak, Thailand

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  • Jacher Viladpai-nguen,

    Affiliation: Shoklo Malaria Research Unit (SMRU), Mae Sot, Tak, Thailand

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  • Lucy Phaiphun,

    Affiliation: Shoklo Malaria Research Unit (SMRU), Mae Sot, Tak, Thailand

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  • Katja Wüstefeld,

    Affiliation: Shoklo Malaria Research Unit (SMRU), Mae Sot, Tak, Thailand

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  • Marion Barends,

    Affiliations: Shoklo Malaria Research Unit (SMRU), Mae Sot, Tak, Thailand, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand

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  • Natthapon Laochan,

    Affiliation: Shoklo Malaria Research Unit (SMRU), Mae Sot, Tak, Thailand

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  • Lily Keereecharoen,

    Affiliation: Shoklo Malaria Research Unit (SMRU), Mae Sot, Tak, Thailand

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  • Niklas Lindegardh,

    Affiliations: Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand, Centre for Clinical Vaccinology and Tropical Medicine, Churchill Hospital, Oxford, United Kingdom

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  • Pratap Singhasivanon,

    Affiliation: Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand

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  • Nicholas J White,

    Affiliations: Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand, Centre for Clinical Vaccinology and Tropical Medicine, Churchill Hospital, Oxford, United Kingdom

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  • François Nosten

    Affiliations: Shoklo Malaria Research Unit (SMRU), Mae Sot, Tak, Thailand, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand, Centre for Clinical Vaccinology and Tropical Medicine, Churchill Hospital, Oxford, United Kingdom

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  • Published: December 23, 2008
  • DOI: 10.1371/journal.pmed.0050253

About the Authors

Rose McGready, Saw Oo Tan, Elizabeth A Ashley, Mupawjay Pimanpanarak, Jacher Viladpai-nguen, Lucy Phaiphun, Katja Wüstefeld, Marion Barends, Natthapon Laochan, Lily Keereecharoen, François Nosten
Shoklo Malaria Research Unit (SMRU), Mae Sot, Tak, Thailand
Rose McGready, Elizabeth A Ashley, Marion Barends, Niklas Lindegardh, Pratap Singhasivanon, Nicholas J White, François Nosten
Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
Rose McGready, Elizabeth A Ashley, Niklas Lindegardh, Nicholas J White, François Nosten
Centre for Clinical Vaccinology and Tropical Medicine, Churchill Hospital, Oxford, United Kingdom

Corresponding Author

Email: rose@shoklo-unit.com

Competing Interests

NJW is co-chairman of the WHO treatment guidelines committee.

Author Contributions

RM, NJW, and FN developed the study protocol. RM, SOT, EAA, MP, JV, LP, and KW oversaw the implementation of the trial, assisted with the data analysis and drafting of the manuscript. LK oversaw the field laboratory work and analysis of the malaria smear results, MB and N Laochan undertook the PCR analysis, and N Lindegardh the lumefantrine analysis. EAA, PS, NJW, and FN contributed to the monitoring of the trial and drafting of the manuscript.