Advertisement
Research Article

Emergence of Azole Resistance in Aspergillus fumigatus and Spread of a Single Resistance Mechanism

  • Eveline Snelders,

    Affiliations: Department of Medical Microbiology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands, Nijmegen Institute for Infectious Diseases, Inflammation and Immunity, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands

    X
  • Henrich A. L van der Lee,

    Affiliations: Department of Medical Microbiology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands, Nijmegen Institute for Infectious Diseases, Inflammation and Immunity, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands

    X
  • Judith Kuijpers,

    Affiliations: Department of Medical Microbiology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands, Nijmegen Institute for Infectious Diseases, Inflammation and Immunity, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands

    X
  • Anthonius J. M. M Rijs,

    Affiliations: Department of Medical Microbiology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands, Nijmegen Institute for Infectious Diseases, Inflammation and Immunity, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands

    X
  • János Varga,

    Affiliations: Centraalbureau voor Schimmelcultures (CBS), Fungal Biodiversity Centre, Utrecht, The Netherlands, Department of Microbiology, Faculty of Science and Informatics, University of Szeged, Hungary

    X
  • Robert A Samson,

    Affiliation: Centraalbureau voor Schimmelcultures (CBS), Fungal Biodiversity Centre, Utrecht, The Netherlands

    X
  • Emilia Mellado,

    Affiliation: Servicio de Micologia, Centro Nacional de Microbiologia, Instituto de Salud Carlos III, Madrid, Spain

    X
  • A. Rogier T Donders,

    Affiliation: Department of Epidemiology and Biostatistics, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands

    X
  • Willem J. G Melchers,

    Affiliations: Department of Medical Microbiology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands, Nijmegen Institute for Infectious Diseases, Inflammation and Immunity, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands

    X
  • Paul E Verweij mail

    To whom correspondence should be addressed. E-mail: p.verweij@mmb.umcn.nl

    Affiliations: Department of Medical Microbiology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands, Nijmegen Institute for Infectious Diseases, Inflammation and Immunity, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands

    X
  • Published: November 11, 2008
  • DOI: 10.1371/journal.pmed.0050219

About the Authors

Eveline Snelders, Henrich A. L van der Lee, Judith Kuijpers, Anthonius J. M. M Rijs, Willem J. G Melchers, Paul E Verweij
Department of Medical Microbiology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
Eveline Snelders, Henrich A. L van der Lee, Judith Kuijpers, Anthonius J. M. M Rijs, Willem J. G Melchers, Paul E Verweij
Nijmegen Institute for Infectious Diseases, Inflammation and Immunity, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
János Varga, Robert A Samson
Centraalbureau voor Schimmelcultures (CBS), Fungal Biodiversity Centre, Utrecht, The Netherlands
János Varga
Department of Microbiology, Faculty of Science and Informatics, University of Szeged, Hungary
Emilia Mellado
Servicio de Micologia, Centro Nacional de Microbiologia, Instituto de Salud Carlos III, Madrid, Spain
A. Rogier T Donders
Department of Epidemiology and Biostatistics, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands

Corresponding Author

Email: p.verweij@mmb.umcn.nl

Competing Interests

PV: Consultant, Merck, Pfizer; research grant, Cephalon, Schering-Plough, Pfizer, Merck, Basilea; speaker's bureau: Gilead, Merck, Schering-Plough. Other authors: no competing interests declared.

Author Contributions

RAS, WJGM, and PEV designed the study. ES, HALvdL, JK, AJMMR, JV, and EM collected data or did experiments for the study. ES, JV, ARTD, WJGM, and PEV analyzed the data. ES wrote the first draft of the paper. RAS, ARTD, WJGM, and PEV contributed to writing the paper.