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Research Article

Inflammatory and Coagulation Biomarkers and Mortality in Patients with HIV Infection

  • Lewis H Kuller,

    Affiliation: University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America

    X
  • Russell Tracy,

    Affiliation: University of Vermont, Burlington, Vermont, United States of America

    X
  • Waldo Belloso,

    Affiliation: Hospital Italiano de Buenos Aires, Buenos Aires, Argentina

    X
  • Stephane De Wit,

    Affiliation: Saint-Pierre Hospital, Brussels, Belgium

    X
  • Fraser Drummond,

    Affiliation: National Centre in HIV Epidemiology and Clinical Research, University of New South Wales, Sydney, Australia

    X
  • H. Clifford Lane,

    Affiliation: National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America

    X
  • Bruno Ledergerber,

    Affiliation: University Hospital, Zurich, Switzerland

    X
  • Jens Lundgren,

    Affiliation: University of Copenhagen, Copenhagen, Denmark

    X
  • Jacqueline Neuhaus,

    Affiliation: University of Minnesota, Minneapolis, Minnesota, United States of America

    X
  • Daniel Nixon,

    Affiliation: Virginia Commonwealth University, Richmond, Virginia, United States of America

    X
  • Nicholas I Paton,

    Affiliation: Medical Research Council Clinical Trials Unit, London, United Kingdom

    X
  • James D Neaton mail,

    To whom correspondence should be addressed. E-mail: jim@ccbr.umn.edu

    Affiliation: University of Minnesota, Minneapolis, Minnesota, United States of America

    X
  • for the INSIGHT SMART Study Group
  • Published: October 21, 2008
  • DOI: 10.1371/journal.pmed.0050203

About the Authors

Lewis H Kuller
University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
Russell Tracy
University of Vermont, Burlington, Vermont, United States of America
Waldo Belloso
Hospital Italiano de Buenos Aires, Buenos Aires, Argentina
Stephane De Wit
Saint-Pierre Hospital, Brussels, Belgium
Fraser Drummond
National Centre in HIV Epidemiology and Clinical Research, University of New South Wales, Sydney, Australia
H. Clifford Lane
National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
Bruno Ledergerber
University Hospital, Zurich, Switzerland
Jens Lundgren
University of Copenhagen, Copenhagen, Denmark
Jacqueline Neuhaus, James D Neaton
University of Minnesota, Minneapolis, Minnesota, United States of America
Daniel Nixon
Virginia Commonwealth University, Richmond, Virginia, United States of America
Nicholas I Paton
Medical Research Council Clinical Trials Unit, London, United Kingdom

Corresponding Author

Email: jim@ccbr.umn.edu

Competing Interests

Bruno Ledergerber reported travel grants, grants or honoraria from Abbott, Aventis, Bristol-Myers Squibb, Gilead, GlaxoSmithKline, Merck Sharp & Dohme, Roche and Tibotec. Jens Lundgren reported honoraria and research grants from Boehringer-Ingelheim, Roche, Abbott, Bristol-Myers Squibb, Merck Sharp & Dohme, GlaxoSmithKline, Tibotec, Pfizer, and Gilead. Russell Tracy reported the following activities: (1) Wake Forest University Pepper Center on Aging—External Advisory Board; (2) Johns Hopkins University Pepper Center on Aging—External Advisory Board; (3) University of Florida Pepper Center on Aging—External Advisory Board; (4) Haematologic Technologies—owner; thrombosis and fibrinolysis biochemical reagents and blood collection tubes; contract research in this area; and (5) Ashcraft & Gerel Attorneys at Law—consulting on mechanisms in inflammation, atherosclerosis and thrombosis.

Author Contributions

All of the authors provided input to drafts of the manuscript. LHK, RT, and JDN are responsible for the design of the biomarker study. RT's laboratory carried out the analyses of the specimens. JDN was a co-chair of the SMART study. JDN and JN carried out data analyses for the paper.