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Research Article

SLC2A9 Is a High-Capacity Urate Transporter in Humans

  • Mark J Caulfield equal contributor mail,

    equal contributor Contributed equally to this work with: Mark J Caulfield, Patricia B Munroe

    To whom correspondence should be addressed. E-mail: m.j.caulfield@qmul.ac.uk

    Affiliation: Clinical Pharmacology and The Genome Centre, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, London, United Kingdom

    X
  • Patricia B Munroe equal contributor,

    equal contributor Contributed equally to this work with: Mark J Caulfield, Patricia B Munroe

    Affiliation: Clinical Pharmacology and The Genome Centre, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, London, United Kingdom

    X
  • Deb O'Neill,

    Affiliation: Department of Physiology, University of Alberta, Edmonton, Alberta, Canada

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  • Kate Witkowska,

    Affiliation: Department of Physiology, University of Alberta, Edmonton, Alberta, Canada

    X
  • Fadi J Charchar,

    Affiliation: Clinical Pharmacology and The Genome Centre, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, London, United Kingdom

    X
  • Manuel Doblado,

    Affiliation: Department of Obstetrics and Gynaecology, Washington University in St Louis School of Medicine, St. Louis, Missouri, United States of America

    X
  • Sarah Evans,

    Affiliation: Department of Obstetrics and Gynaecology, Washington University in St Louis School of Medicine, St. Louis, Missouri, United States of America

    X
  • Susana Eyheramendy,

    Affiliation: Department of Statistics, Pontificia Universidad Católica de Chile, Santiago, Chile

    X
  • Abiodun Onipinla,

    Affiliation: Clinical Pharmacology and The Genome Centre, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, London, United Kingdom

    X
  • Philip Howard,

    Affiliation: Clinical Pharmacology and The Genome Centre, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, London, United Kingdom

    X
  • Sue Shaw-Hawkins,

    Affiliation: Clinical Pharmacology and The Genome Centre, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, London, United Kingdom

    X
  • Richard J Dobson,

    Affiliation: Clinical Pharmacology and The Genome Centre, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, London, United Kingdom

    X
  • Chris Wallace,

    Affiliation: Clinical Pharmacology and The Genome Centre, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, London, United Kingdom

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  • Stephen J Newhouse,

    Affiliation: Clinical Pharmacology and The Genome Centre, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, London, United Kingdom

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  • Morris Brown,

    Affiliation: Clinical Pharmacology Unit, University of Cambridge, Addenbrookes Hospital, Cambridge, United Kingdom

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  • John M Connell,

    Affiliation: Glasgow Cardiovascular Research Centre, University of Glasgow, Glasgow, United Kingdom

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  • Anna Dominiczak,

    Affiliation: Glasgow Cardiovascular Research Centre, University of Glasgow, Glasgow, United Kingdom

    X
  • Martin Farrall,

    Affiliation: Cardiovascular Medicine, University of Oxford, Wellcome Trust Centre for Human Genetics, Oxford, United Kingdom

    X
  • G. Mark Lathrop,

    Affiliation: Centre National de Génotypage, Evry, France

    X
  • Nilesh J Samani,

    Affiliations: Cardiovascular Sciences, University of Leicester, Glenfield Hospital, Leicester, United Kingdom, Epidemiology and Public Health, University College, London, United Kingdom

    X
  • Meena Kumari,

    Affiliation: Epidemiology and Public Health, University College, London, United Kingdom

    X
  • Michael Marmot,

    Affiliation: Epidemiology and Public Health, University College, London, United Kingdom

    X
  • Eric Brunner,

    Affiliation: Epidemiology and Public Health, University College, London, United Kingdom

    X
  • John Chambers,

    Affiliation: National Heart Lung Institute and Epidemiology and Public Health, Imperial College, London, United Kingdom

    X
  • Paul Elliott,

    Affiliation: National Heart Lung Institute and Epidemiology and Public Health, Imperial College, London, United Kingdom

    X
  • Jaspal Kooner,

    Affiliation: National Heart Lung Institute and Epidemiology and Public Health, Imperial College, London, United Kingdom

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  • Maris Laan,

    Affiliation: Institute of Molecular and Cell Biology, University of Tartu, Tartu, Estonia

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  • Elin Org,

    Affiliation: Institute of Molecular and Cell Biology, University of Tartu, Tartu, Estonia

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  • Gudrun Veldre,

    Affiliations: Institute of Molecular and Cell Biology, University of Tartu, Tartu, Estonia, Department of Cardiology, University of Tartu, Tartu, Estonia

    X
  • Margus Viigimaa,

    Affiliation: Centre of Cardiology, North Estonia Medical Centre, Tallinn, Estonia

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  • Francesco P Cappuccio,

    Affiliation: Cardiovascular Medicine and Epidemiology, Clinical Sciences Research Institute, University of Warwick Medical School, Clifford Bridge Road, Coventry, United Kingdom

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  • Chen Ji,

    Affiliation: Cardiovascular Medicine and Epidemiology, Clinical Sciences Research Institute, University of Warwick Medical School, Clifford Bridge Road, Coventry, United Kingdom

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  • Roberto Iacone,

    Affiliation: Department of Clinical and Experimental Medicine, Federico II University of Naples Medical School, Naples, Italy

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  • Pasquale Strazzullo,

    Affiliation: Department of Clinical and Experimental Medicine, Federico II University of Naples Medical School, Naples, Italy

    X
  • Kelle H Moley,

    Affiliation: Department of Obstetrics and Gynaecology, Washington University in St Louis School of Medicine, St. Louis, Missouri, United States of America

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  • Chris Cheeseman

    Affiliation: Department of Physiology, University of Alberta, Edmonton, Alberta, Canada

    X
  • Published: October 07, 2008
  • DOI: 10.1371/journal.pmed.0050197

About the Authors

Mark J Caulfield, Patricia B Munroe, Fadi J Charchar, Abiodun Onipinla, Philip Howard, Sue Shaw-Hawkins, Richard J Dobson, Chris Wallace, Stephen J Newhouse
Clinical Pharmacology and The Genome Centre, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, London, United Kingdom
Deb O'Neill, Kate Witkowska, Chris Cheeseman
Department of Physiology, University of Alberta, Edmonton, Alberta, Canada
Manuel Doblado, Sarah Evans, Kelle H Moley
Department of Obstetrics and Gynaecology, Washington University in St Louis School of Medicine, St. Louis, Missouri, United States of America
Susana Eyheramendy
Department of Statistics, Pontificia Universidad Católica de Chile, Santiago, Chile
Morris Brown
Clinical Pharmacology Unit, University of Cambridge, Addenbrookes Hospital, Cambridge, United Kingdom
John M Connell, Anna Dominiczak
Glasgow Cardiovascular Research Centre, University of Glasgow, Glasgow, United Kingdom
Martin Farrall
Cardiovascular Medicine, University of Oxford, Wellcome Trust Centre for Human Genetics, Oxford, United Kingdom
G. Mark Lathrop
Centre National de Génotypage, Evry, France
Nilesh J Samani
Cardiovascular Sciences, University of Leicester, Glenfield Hospital, Leicester, United Kingdom
Nilesh J Samani, Meena Kumari, Michael Marmot, Eric Brunner
Epidemiology and Public Health, University College, London, United Kingdom
John Chambers, Paul Elliott, Jaspal Kooner
National Heart Lung Institute and Epidemiology and Public Health, Imperial College, London, United Kingdom
Maris Laan, Elin Org, Gudrun Veldre
Institute of Molecular and Cell Biology, University of Tartu, Tartu, Estonia
Gudrun Veldre
Department of Cardiology, University of Tartu, Tartu, Estonia
Margus Viigimaa
Centre of Cardiology, North Estonia Medical Centre, Tallinn, Estonia
Francesco P Cappuccio, Chen Ji
Cardiovascular Medicine and Epidemiology, Clinical Sciences Research Institute, University of Warwick Medical School, Clifford Bridge Road, Coventry, United Kingdom
Roberto Iacone, Pasquale Strazzullo
Department of Clinical and Experimental Medicine, Federico II University of Naples Medical School, Naples, Italy

Corresponding Author

Email: m.j.caulfield@qmul.ac.uk

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

M.J. Caulfield, P.B. Munroe, F.J. Charchar, K.H. Moley, and C. Cheeseman contributed to study design, execution, planning, analysis, and writing of the manuscript. D. O'Neill, K. Witkowska, M. Doblado, S. Evans, P. Howard, S. Newhouse, A. Onipinla, S. Shaw-Hawkins, R. Dobson, C. Wallace, M. Brown, J. Connell, A. Dominiczak, G.M. Lathrop, N.J. Samani, M. Marmot, E. Brunner, J. Chambers, P. Elliott, J. Kooner, M. Laan, E. Org, G. Veldre, and M. Viigimaa contributed to design and execution of the study. S. Eyheramendy, M. Farrall, M. Kumari, F. Cappuccio, C. Ji, R. Iacone, and P. Strazzullo contributed to design, execution, and analysis.