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Research Article

Vitamin K Supplementation in Postmenopausal Women with Osteopenia (ECKO Trial): A Randomized Controlled Trial

  • Angela M Cheung mail,

    To whom correspondence should be addressed. E-mail: angela.cheung@uhn.on.ca

    Affiliations: Division of General Internal Medicine, Department of Medicine, University of Toronto, Toronto, Ontario, Canada, Division of Endocrinology, Department of Medicine, University of Toronto, Toronto, Ontario, Canada, Clinical Epidemiology Program, Department of Health Policy, Management and Evaluation, University of Toronto, Toronto, Ontario, Canada, Osteoporosis and Women's Health Programs, University Health Network, Toronto, Ontario, Canada

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  • Lianne Tile,

    Affiliations: Division of General Internal Medicine, Department of Medicine, University of Toronto, Toronto, Ontario, Canada, Osteoporosis and Women's Health Programs, University Health Network, Toronto, Ontario, Canada

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  • Yuna Lee,

    Affiliation: Division of General Internal Medicine, Department of Medicine, University of Toronto, Toronto, Ontario, Canada

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  • George Tomlinson,

    Affiliations: Division of General Internal Medicine, Department of Medicine, University of Toronto, Toronto, Ontario, Canada, Clinical Epidemiology Program, Department of Health Policy, Management and Evaluation, University of Toronto, Toronto, Ontario, Canada

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  • Gillian Hawker,

    Affiliations: Clinical Epidemiology Program, Department of Health Policy, Management and Evaluation, University of Toronto, Toronto, Ontario, Canada, Division of Rheumatology, Department of Medicine, University of Toronto, Toronto, Ontario, Canada

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  • Judy Scher,

    Affiliation: Osteoporosis and Women's Health Programs, University Health Network, Toronto, Ontario, Canada

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  • Hanxian Hu,

    Affiliation: Osteoporosis and Women's Health Programs, University Health Network, Toronto, Ontario, Canada

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  • Reinhold Vieth,

    Affiliation: Department of Pathology and Laboratory Medicine, University of Toronto, Toronto, Ontario, Canada

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  • Lilian Thompson,

    Affiliation: Department of Nutritional Sciences, University of Toronto, Toronto, Ontario, Canada

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  • Sophie Jamal,

    Affiliations: Division of Endocrinology, Department of Medicine, University of Toronto, Toronto, Ontario, Canada, Clinical Epidemiology Program, Department of Health Policy, Management and Evaluation, University of Toronto, Toronto, Ontario, Canada

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  • Robert Josse

    Affiliation: Division of Endocrinology, Department of Medicine, University of Toronto, Toronto, Ontario, Canada

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  • Published: October 14, 2008
  • DOI: 10.1371/journal.pmed.0050196

About the Authors

Angela M Cheung, Lianne Tile, Yuna Lee, George Tomlinson
Division of General Internal Medicine, Department of Medicine, University of Toronto, Toronto, Ontario, Canada
Angela M Cheung, Sophie Jamal, Robert Josse
Division of Endocrinology, Department of Medicine, University of Toronto, Toronto, Ontario, Canada
Angela M Cheung, George Tomlinson, Gillian Hawker, Sophie Jamal
Clinical Epidemiology Program, Department of Health Policy, Management and Evaluation, University of Toronto, Toronto, Ontario, Canada
Angela M Cheung, Lianne Tile, Judy Scher, Hanxian Hu
Osteoporosis and Women's Health Programs, University Health Network, Toronto, Ontario, Canada
Gillian Hawker
Division of Rheumatology, Department of Medicine, University of Toronto, Toronto, Ontario, Canada
Reinhold Vieth
Department of Pathology and Laboratory Medicine, University of Toronto, Toronto, Ontario, Canada
Lilian Thompson
Department of Nutritional Sciences, University of Toronto, Toronto, Ontario, Canada

Corresponding Author

Email: angela.cheung@uhn.on.ca

Competing Interests

The corresponding author had full access to all the data in the study and had final responsibility for the decision to submit for publication. None of the authors in this study has any competing interests.

Author Contributions

A.M. Cheung, G. Hawker, and R. Josse were involved in the conception and design of the study; A.M. Cheung, L. Tile, Y. Lee, J. Scher, and H. Hu performed data acquisition; A.M. Cheung, L. Tile, Y. Lee, G. Tomlinson, G. Hawker, J. Scher, H. Hu, R. Vieth, L. Thompson, S. Jamal, and R. Josse analyzed and interpreted data; A.M. Cheung and J. Scher drafted the manuscript; A.M. Cheung, L. Tile, Y. Lee, G. Tomlinson, G. Hawker, J. Scher, H. Hu, R. Vieth, L. Thompson, S. Jamal, and R. Josse critically revised the manuscript for important intellectual content; G. Tomlinson and H. Hu performed statistical analysis; A.M. Cheung obtained funding; A.M. Cheung, L. Tile, Y. Lee, G. Tomlinson, G. Hawker, J. Scher, H. Hu, R. Vieth, and R. Josse provided administrative, technical, or material support; AMC supervised entire study.