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Research Article

Lung Cancer Occurrence in Never-Smokers: An Analysis of 13 Cohorts and 22 Cancer Registry Studies

  • Michael J Thun mail,

    To whom correspondence should be addressed. E-mail: mthun@cancer.org

    Affiliation: American Cancer Society, Atlanta, Georgia, United States of America

    X
  • Lindsay M Hannan,

    Affiliation: American Cancer Society, Atlanta, Georgia, United States of America

    X
  • Lucile L Adams-Campbell,

    Affiliation: Howard University Cancer Center, Washington, D. C., United States of America

    X
  • Paolo Boffetta,

    Affiliation: International Agency for Research on Cancer (IARC), Lyon, France

    X
  • Julie E Buring,

    Affiliation: Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America

    X
  • Diane Feskanich,

    Affiliation: Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America

    X
  • W. Dana Flanders,

    Affiliations: American Cancer Society, Atlanta, Georgia, United States of America, Rollins School of Public Health, Emory University, Atlanta, Georgia, United States of America

    X
  • Sun Ha Jee,

    Affiliation: Institute for Health Promotion, Graduate School of Public Health, Yonsei University, Seoul, Korea

    X
  • Kota Katanoda,

    Affiliation: Cancer Information Services and Surveillance Division, Center for Cancer Control and Information Services, National Cancer Center, Tokyo, Japan

    X
  • Laurence N Kolonel,

    Affiliation: Cancer Research Center of Hawaii, University of Hawaii, Honolulu, Hawaii, United States of America

    X
  • I-Min Lee,

    Affiliation: Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America

    X
  • Tomomi Marugame,

    Affiliation: Cancer Information Services and Surveillance Division, Center for Cancer Control and Information Services, National Cancer Center, Tokyo, Japan

    X
  • Julie R Palmer,

    Affiliation: Slone Epidemiology Center, Boston University, Boston, Massachusetts, United States of America

    X
  • Elio Riboli,

    Affiliation: International Agency for Research on Cancer (IARC), Lyon, France

    X
  • Tomotaka Sobue,

    Affiliation: Cancer Information Services and Surveillance Division, Center for Cancer Control and Information Services, National Cancer Center, Tokyo, Japan

    X
  • Erika Avila-Tang,

    Affiliation: Department of Epidemiology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, United States of America

    X
  • Lynne R Wilkens,

    Affiliation: Cancer Research Center of Hawaii, University of Hawaii, Honolulu, Hawaii, United States of America

    X
  • Jon M Samet

    Affiliation: Department of Epidemiology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, United States of America

    X
  • Published: September 09, 2008
  • DOI: 10.1371/journal.pmed.0050185

About the Authors

Michael J Thun, Lindsay M Hannan, W. Dana Flanders
American Cancer Society, Atlanta, Georgia, United States of America
Lucile L Adams-Campbell
Howard University Cancer Center, Washington, D. C., United States of America
Paolo Boffetta, Elio Riboli
International Agency for Research on Cancer (IARC), Lyon, France
Julie E Buring, Diane Feskanich, I-Min Lee
Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America
W. Dana Flanders
Rollins School of Public Health, Emory University, Atlanta, Georgia, United States of America
Sun Ha Jee
Institute for Health Promotion, Graduate School of Public Health, Yonsei University, Seoul, Korea
Kota Katanoda, Tomomi Marugame, Tomotaka Sobue
Cancer Information Services and Surveillance Division, Center for Cancer Control and Information Services, National Cancer Center, Tokyo, Japan
Laurence N Kolonel, Lynne R Wilkens
Cancer Research Center of Hawaii, University of Hawaii, Honolulu, Hawaii, United States of America
Julie R Palmer
Slone Epidemiology Center, Boston University, Boston, Massachusetts, United States of America
Erika Avila-Tang, Jon M Samet
Department of Epidemiology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, United States of America

Corresponding Author

Email: mthun@cancer.org

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

The study was jointly conceived by MJT, PB, and JMS, and written by MJT, LMH, LLA-C, PB, JEB, DF, WDF, SHJ, KK, LNK, IML, TM, JRP, ER, TS, EAT, LRW, and JMS. MJT, LMH, and WDF compiled and analyzed the data.