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Research Article

Cancer Screening: A Mathematical Model Relating Secreted Blood Biomarker Levels to Tumor Sizes

  • Amelie M Lutz,

    Affiliation: Department of Radiology, Stanford University School of Medicine, Stanford, California, United States of America

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  • Juergen K Willmann,

    Affiliation: Department of Radiology, Stanford University School of Medicine, Stanford, California, United States of America

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  • Frank V Cochran,

    Affiliation: Department of Radiology, Stanford University School of Medicine, Stanford, California, United States of America

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  • Pritha Ray,

    Affiliation: Department of Radiology, Stanford University School of Medicine, Stanford, California, United States of America

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  • Sanjiv S Gambhir mail

    To whom correspondence should be addressed. E-mail: sgambhir@stanford.edu

    Affiliations: Department of Radiology, Stanford University School of Medicine, Stanford, California, United States of America, Department of Bioengineering, the Bio-X Program, Stanford University School of Medicine, Stanford, California, United States of America

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  • Published: August 19, 2008
  • DOI: 10.1371/journal.pmed.0050170

About the Authors

Amelie M Lutz, Juergen K Willmann, Frank V Cochran, Pritha Ray, Sanjiv S Gambhir
Department of Radiology, Stanford University School of Medicine, Stanford, California, United States of America
Sanjiv S Gambhir
Department of Bioengineering, the Bio-X Program, Stanford University School of Medicine, Stanford, California, United States of America

Corresponding Author

Email: sgambhir@stanford.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

SSG designed the mathematical model/strategy. AML, JKW, and SSG designed the experiments/the study. AML and JKW collected data or did experiments for the study. AML and SSG analyzed the data. AML and SSG wrote the first draft of the paper. AML, JKW, FVC, PR, and SSG contributed to the writing of the paper.