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Research Article

Greater Response to Placebo in Children Than in Adults: A Systematic Review and Meta-Analysis in Drug-Resistant Partial Epilepsy

  • Sylvain Rheims,

    Affiliations: Department of Functional Neurology and Epileptology, Hospices Civils de Lyon, Lyon, France, CTRS INSERM-IDEE, Institute for Children and Adolescents with Epilepsy, Hospices Civils de Lyon, Lyon, France

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  • Michel Cucherat,

    Affiliation: Department of Clinical Pharmacology, EA 643, Lyon-1 University, Laennec Faculty of Medicine, Lyon, France

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  • Alexis Arzimanoglou,

    Affiliations: CTRS INSERM-IDEE, Institute for Children and Adolescents with Epilepsy, Hospices Civils de Lyon, Lyon, France, Department of Epileptology, Sleep and Pediatric Neurophysiology, Hospices Civils de Lyon, Lyon, France

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  • Philippe Ryvlin mail

    To whom correspondence should be addressed. E-mail: ryvlin@cermep.fr

    Affiliations: Department of Functional Neurology and Epileptology, Hospices Civils de Lyon, Lyon, France, CTRS INSERM-IDEE, Institute for Children and Adolescents with Epilepsy, Hospices Civils de Lyon, Lyon, France, INSERM U821, Lyon, France

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  • Published: August 12, 2008
  • DOI: 10.1371/journal.pmed.0050166

About the Authors

Sylvain Rheims, Philippe Ryvlin
Department of Functional Neurology and Epileptology, Hospices Civils de Lyon, Lyon, France
Sylvain Rheims, Alexis Arzimanoglou, Philippe Ryvlin
CTRS INSERM-IDEE, Institute for Children and Adolescents with Epilepsy, Hospices Civils de Lyon, Lyon, France
Michel Cucherat
Department of Clinical Pharmacology, EA 643, Lyon-1 University, Laennec Faculty of Medicine, Lyon, France
Alexis Arzimanoglou
Department of Epileptology, Sleep and Pediatric Neurophysiology, Hospices Civils de Lyon, Lyon, France
Philippe Ryvlin
INSERM U821, Lyon, France

Corresponding Author

Email: ryvlin@cermep.fr

Competing Interests

SR has received speaker fees from Pfizer. MC has no conflict of interest. AA has received speaker or consultant fees from Pfizer, Sanofi-Aventis, GlaxoSmithKline (GSK), Jansen-Cilag, UCB Pharma, EISAI, and Valeant. PR has received speaker fees from Cyberonics, Eisai, GSK, Janssen-Cilag, Novartis, Pfizer, Sanofi-Synthelabo, and UCB; and consultant fees from Cyberonics, GSK, Janssen-Cilag, Novartis, Pfizer, UCB, and Valeant.