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Research Article

Prevention of SIV Rectal Transmission and Priming of T Cell Responses in Macaques after Local Pre-exposure Application of Tenofovir Gel

  • Martin Cranage mail,

    To whom correspondence should be addressed. E-mail: mcranage@sgul.ac.uk

    Affiliation: Centre for Infection, Division of Cellular & Molecular Medicine, St George's University of London, London, United Kingdom

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  • Sally Sharpe,

    Affiliation: Centre for Emergency Preparedness and Response, Health Protection Agency, Porton Down, Salisbury, United Kingdom

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  • Carolina Herrera,

    Affiliation: Centre for Infection, Division of Cellular & Molecular Medicine, St George's University of London, London, United Kingdom

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  • Alethea Cope,

    Affiliation: Centre for Infection, Division of Cellular & Molecular Medicine, St George's University of London, London, United Kingdom

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  • Mike Dennis,

    Affiliation: Centre for Emergency Preparedness and Response, Health Protection Agency, Porton Down, Salisbury, United Kingdom

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  • Neil Berry,

    Affiliation: Division of Retrovirology, National Institute for Biological Standards & Control, South Mimms, United Kingdom

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  • Claire Ham,

    Affiliation: Division of Retrovirology, National Institute for Biological Standards & Control, South Mimms, United Kingdom

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  • Jonathan Heeney,

    Affiliations: Department of Virology, Biomedical Primate Research Centre, Rijswijk, The Netherlands, Department of Veterinary Medicine, University of Cambridge, Cambridge, United Kingdom

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  • Naser Rezk,

    Affiliation: University of North Carolina Centers for Aids Research (CFAR) Clinical Pharmacology and Analytical Chemistry Core, Chapel Hill, North Carolina, United States of America

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  • Angela Kashuba,

    Affiliation: University of North Carolina Centers for Aids Research (CFAR) Clinical Pharmacology and Analytical Chemistry Core, Chapel Hill, North Carolina, United States of America

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  • Peter Anton,

    Affiliation: Center for Prevention Research, David Geffen School of Medicine at the University of California Los Angeles (UCLA), Los Angeles, California, United States of America

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  • Ian McGowan,

    Affiliation: Center for Prevention Research, David Geffen School of Medicine at the University of California Los Angeles (UCLA), Los Angeles, California, United States of America

    ¤ Current address: Magee Womens Research Institute, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America

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  • Robin Shattock

    Affiliation: Centre for Infection, Division of Cellular & Molecular Medicine, St George's University of London, London, United Kingdom

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  • Published: August 05, 2008
  • DOI: 10.1371/journal.pmed.0050157

About the Authors

Martin Cranage, Carolina Herrera, Alethea Cope, Robin Shattock
Centre for Infection, Division of Cellular & Molecular Medicine, St George's University of London, London, United Kingdom
Sally Sharpe, Mike Dennis
Centre for Emergency Preparedness and Response, Health Protection Agency, Porton Down, Salisbury, United Kingdom
Neil Berry, Claire Ham
Division of Retrovirology, National Institute for Biological Standards & Control, South Mimms, United Kingdom
Jonathan Heeney
Department of Virology, Biomedical Primate Research Centre, Rijswijk, The Netherlands
Jonathan Heeney
Department of Veterinary Medicine, University of Cambridge, Cambridge, United Kingdom
Naser Rezk, Angela Kashuba
University of North Carolina Centers for Aids Research (CFAR) Clinical Pharmacology and Analytical Chemistry Core, Chapel Hill, North Carolina, United States of America
Peter Anton, Ian McGowan
Center for Prevention Research, David Geffen School of Medicine at the University of California Los Angeles (UCLA), Los Angeles, California, United States of America

Corresponding Author

Email: mcranage@sgul.ac.uk

Competing Interests

The authors declare no competing financial interests.

Author Contributions

MC, SS, and RS designed the experiments; SS and MD were responsible for the in vivo work; C. Herrera performed the explant experiments; AC performed the ELISpot experiments; NB, C. Ham, and JH performed the quantitative PCR analyses; NR and AK were responsible for the assay of tenofovir; PA coordinated the overall Microbicide Development Programme; IMcG had oversight of the preclinical testing project; and MC wrote the manuscript.