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Research Article

Gene-Environment Interaction in the Onset of Eczema in Infancy: Filaggrin Loss-of-Function Mutations Enhanced by Neonatal Cat Exposure

  • Hans Bisgaard mail,

    To whom correspondence should be addressed. E-mail: bisgaard@copsac.com

    Affiliation: Copenhagen Prospective Studies on Asthma in Childhood, Danish Paediatric Asthma Centre, Copenhagen, University Hospital Gentofte, Copenhagen, Denmark

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  • Angela Simpson,

    Affiliation: School of Translational Medicine, University of Manchester, University Hospital of South Manchester National Health Service Foundation Trust, Manchester, United Kingdom

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  • Colin N.A Palmer,

    Affiliation: Population Pharmacogenetics Group, Biomedical Research Centre, Ninewells Hospital and Medical School, University of Dundee, Dundee, United Kingdom

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  • Klaus Bønnelykke,

    Affiliation: Copenhagen Prospective Studies on Asthma in Childhood, Danish Paediatric Asthma Centre, Copenhagen, University Hospital Gentofte, Copenhagen, Denmark

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  • Irwin Mclean,

    Affiliation: Population Pharmacogenetics Group, Biomedical Research Centre, Ninewells Hospital and Medical School, University of Dundee, Dundee, United Kingdom

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  • Somnath Mukhopadhyay,

    Affiliation: Royal Alexandra Children's Hospital, Brighton and Sussex Medical School, Brighton, United Kingdom

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  • Christian B Pipper,

    Affiliation: Copenhagen Prospective Studies on Asthma in Childhood, Danish Paediatric Asthma Centre, Copenhagen, University Hospital Gentofte, Copenhagen, Denmark

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  • Liselotte B Halkjaer,

    Affiliation: Copenhagen Prospective Studies on Asthma in Childhood, Danish Paediatric Asthma Centre, Copenhagen, University Hospital Gentofte, Copenhagen, Denmark

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  • Brian Lipworth,

    Affiliation: Asthma and Allergy Research Group, Division of Medicine and Therapeutics, Ninewells Hospital and Medical School, University of Dundee, Scotland, United Kingdom

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  • Jenny Hankinson,

    Affiliation: School of Translational Medicine, University of Manchester, University Hospital of South Manchester National Health Service Foundation Trust, Manchester, United Kingdom

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  • Ashley Woodcock,

    Affiliation: School of Translational Medicine, University of Manchester, University Hospital of South Manchester National Health Service Foundation Trust, Manchester, United Kingdom

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  • Adnan Custovic

    Affiliation: School of Translational Medicine, University of Manchester, University Hospital of South Manchester National Health Service Foundation Trust, Manchester, United Kingdom

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  • Published: June 24, 2008
  • DOI: 10.1371/journal.pmed.0050131

About the Authors

Hans Bisgaard, Klaus Bønnelykke, Christian B Pipper, Liselotte B Halkjaer
Copenhagen Prospective Studies on Asthma in Childhood, Danish Paediatric Asthma Centre, Copenhagen, University Hospital Gentofte, Copenhagen, Denmark
Angela Simpson, Jenny Hankinson, Ashley Woodcock, Adnan Custovic
School of Translational Medicine, University of Manchester, University Hospital of South Manchester National Health Service Foundation Trust, Manchester, United Kingdom
Colin N.A Palmer, Irwin Mclean
Population Pharmacogenetics Group, Biomedical Research Centre, Ninewells Hospital and Medical School, University of Dundee, Dundee, United Kingdom
Somnath Mukhopadhyay
Royal Alexandra Children's Hospital, Brighton and Sussex Medical School, Brighton, United Kingdom
Brian Lipworth
Asthma and Allergy Research Group, Division of Medicine and Therapeutics, Ninewells Hospital and Medical School, University of Dundee, Scotland, United Kingdom

Corresponding Author

Email: bisgaard@copsac.com

Competing Interests

HB has been a consultant to, paid lecturer for, and holds sponsored grants from AstraZeneca, GSK, Merck, MedImmune, NeoLab, and Pfizer. He does not hold stock or options in any pharmaceutical company in the respiratory field. IM has filed two patents relating to genetic testing and therapy development aimed at the filaggrin gene. AC receives grant and research support from GlaxoSmithKline and is a consultant for GlaxoSmithKline and UCB Pharma, ALK; and at the speaker's bureau of Astra-Zeneca, GlaxoSmithKline, and UCB Pharma, ALK.

Author Contributions

HB, CNAP, and AC conceived and designed the study and obtained funding. KB and LBH collected and assembled the data. HB and AC analysed and interpreted the data. CBP provided statistical expertise. HB drafted the article. AS, CNAP, KB, IM, SM, CBP, LBH, BL, JH, AW, and AC contributed to the critical revision of the article for important intellectual content. HB, AS, CNAP, KB, IM, SM, CBP, LBH, BL, JH, AW, and AC contributed to the final approval of the article and provision of study materials or patients.