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Research Article

Plasmodium vivax and Mixed Infections Are Associated with Severe Malaria in Children: A Prospective Cohort Study from Papua New Guinea

  • Blaise Genton mail,

    To whom correspondence should be addressed. E-mail: Blaise.Genton@unibas.ch

    Affiliation: Swiss Tropical Institute, Basel, Switzerland

    ¤ Current address: Ifakara Health Research and Development Center, Dar Es Salaam, United Republic of Tanzania

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  • Valérie D'Acremont,

    Affiliation: Swiss Tropical Institute, Basel, Switzerland

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  • Lawrence Rare,

    Affiliation: Papua New Guinea (PNG) Institute of Medical Research (IMR), Goroka, Papua New Guinea

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  • Kay Baea,

    Affiliation: Papua New Guinea (PNG) Institute of Medical Research (IMR), Goroka, Papua New Guinea

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  • John C Reeder,

    Affiliation: Papua New Guinea (PNG) Institute of Medical Research (IMR), Goroka, Papua New Guinea

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  • Michael P Alpers,

    Affiliation: Papua New Guinea (PNG) Institute of Medical Research (IMR), Goroka, Papua New Guinea

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  • Ivo Müller

    Affiliation: Papua New Guinea (PNG) Institute of Medical Research (IMR), Goroka, Papua New Guinea

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  • Published: June 17, 2008
  • DOI: 10.1371/journal.pmed.0050127

About the Authors

Blaise Genton, Valérie D'Acremont
Swiss Tropical Institute, Basel, Switzerland
Lawrence Rare, Kay Baea, John C Reeder, Michael P Alpers, Ivo Müller
Papua New Guinea (PNG) Institute of Medical Research (IMR), Goroka, Papua New Guinea

Corresponding Author

Email: Blaise.Genton@unibas.ch

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

BG designed the study, performed clinical supervision and data checking, and wrote the manuscript. VDA was responsible for data cleaning and analysis. LR was responsible for the demography surveillance system and for the day-to-day activities in the Wosera. KB was the research nurse in charge and on-site microscopist. JCR was the PNG IMR director for the second part of the morbidity surveillance, in charge of overall activities. MPA was the former PNG IMR director; he designed the study and was in charge of overall activities for half of the study period. IM was in charge of data base management and coordinated the malaria activities on site for the second part of the study period.