Advertisement
Research Article

Improving Melanoma Classification by Integrating Genetic and Morphologic Features

  • Amaya Viros,

    Affiliation: Department of Dermatology, University of California San Francisco, San Francisco, California, United States of America

    X
  • Jane Fridlyand,

    Affiliations: University of California San Francisco (UCSF) Comprehensive Cancer Center, University of California San Francisco, San Francisco, California, United States of America, Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, California, United States of America

    X
  • Juergen Bauer,

    Affiliation: Department of Dermatology, University of California San Francisco, San Francisco, California, United States of America

    X
  • Konstantin Lasithiotakis,

    Affiliation: Department of Dermatology, University of Tübingen, Tübingen, Germany

    X
  • Claus Garbe,

    Affiliation: Department of Dermatology, University of Tübingen, Tübingen, Germany

    X
  • Daniel Pinkel,

    Affiliations: University of California San Francisco (UCSF) Comprehensive Cancer Center, University of California San Francisco, San Francisco, California, United States of America, Department of Laboratory Medicine, University of California San Francisco, San Francisco, California, United States of America

    X
  • Boris C Bastian mail

    To whom correspondence should be addressed. E-mail: bastian@cc.ucsf.edu

    Affiliations: Department of Dermatology, University of California San Francisco, San Francisco, California, United States of America, University of California San Francisco (UCSF) Comprehensive Cancer Center, University of California San Francisco, San Francisco, California, United States of America, Department of Pathology, University of California San Francisco, San Francisco, California, United States of America

    X
  • Published: June 03, 2008
  • DOI: 10.1371/journal.pmed.0050120

About the Authors

Amaya Viros, Juergen Bauer, Boris C Bastian
Department of Dermatology, University of California San Francisco, San Francisco, California, United States of America
Jane Fridlyand, Daniel Pinkel, Boris C Bastian
University of California San Francisco (UCSF) Comprehensive Cancer Center, University of California San Francisco, San Francisco, California, United States of America
Jane Fridlyand
Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, California, United States of America
Konstantin Lasithiotakis, Claus Garbe
Department of Dermatology, University of Tübingen, Tübingen, Germany
Daniel Pinkel
Department of Laboratory Medicine, University of California San Francisco, San Francisco, California, United States of America
Boris C Bastian
Department of Pathology, University of California San Francisco, San Francisco, California, United States of America

Corresponding Author

Email: bastian@cc.ucsf.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

AV performed the quantitation of the microscopic features and was involved in the project design, statistical analysis, and writing of the manuscript. JF is responsible for the statistical analysis. JB performed sequencing of BRAF and NRAS in a subset of the samples and was involved in scoring of microscopic features of a subset of the samples. KL and CG performed the statistical analysis of the Southern German Tumor Registry cohort. DP participated in the design of the study and the writing of the manuscript. BCB oversaw the entire project and was involved in the overall project design, data analysis, and writing of the manuscript.