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Research Article

Decreased Brain Volume in Adults with Childhood Lead Exposure

  • Kim M Cecil mail,

    To whom correspondence should be addressed. E-mail: kim.cecil@cchmc.org

    Affiliations: Cincinnati Children's Environmental Health Center, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, United States of America, Department of Radiology, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States of America, Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States of America

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  • Christopher J Brubaker,

    Affiliation: Department of Radiology, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States of America

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  • Caleb M Adler,

    Affiliation: Department of Psychiatry, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States of America

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  • Kim N Dietrich,

    Affiliations: Cincinnati Children's Environmental Health Center, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, United States of America, Department of Environmental Health, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States of America

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  • Mekibib Altaye,

    Affiliation: Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States of America

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  • John C Egelhoff,

    Affiliation: Department of Radiology, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States of America

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  • Stephanie Wessel,

    Affiliations: Cincinnati Children's Environmental Health Center, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, United States of America, Department of Environmental Health, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States of America

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  • Ilayaraja Elangovan,

    Affiliation: Department of Radiology, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States of America

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  • Richard Hornung,

    Affiliations: Cincinnati Children's Environmental Health Center, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, United States of America, Department of Environmental Health, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States of America

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  • Kelly Jarvis,

    Affiliation: Department of Psychiatry, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States of America

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  • Bruce P Lanphear

    Affiliations: Cincinnati Children's Environmental Health Center, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, United States of America, Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States of America, Department of Environmental Health, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States of America

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  • Published: May 27, 2008
  • DOI: 10.1371/journal.pmed.0050112

About the Authors

Kim M Cecil, Kim N Dietrich, Stephanie Wessel, Richard Hornung, Bruce P Lanphear
Cincinnati Children's Environmental Health Center, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, United States of America
Kim M Cecil, Christopher J Brubaker, John C Egelhoff, Ilayaraja Elangovan
Department of Radiology, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States of America
Kim M Cecil, Mekibib Altaye, Bruce P Lanphear
Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States of America
Caleb M Adler, Kelly Jarvis
Department of Psychiatry, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States of America
Kim N Dietrich, Stephanie Wessel, Richard Hornung, Bruce P Lanphear
Department of Environmental Health, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States of America

Corresponding Author

Email: kim.cecil@cchmc.org

Competing Interests

Two of the study's authors, BPL and RH, are on the editorial board of PLoS Medicine. BPL and KND sporadically serve as expert witnesses without personal financial gain.

Author Contributions

KMC, CJB, KND, and BPL designed the experiments/the study. CJB, KND, JCE, and SW collected data or did experiments for the study. KMC, CJB, CMA, KND, MA, IE, and KJ analyzed the data. KMC, KND, and SW enrolled patients. KMC wrote the first draft of the paper. KMC, CJB, CMA, SW, RH, and BPL contributed to writing the paper. CJB designed part of the experiments/study and performed all the analysis. JCE reviewed the MRI studies. KMC, KND, and BPL participated in original conception of study, study design, and interpretation of results.