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Research Article

A Systematic Review of Studies That Aim to Determine Which Outcomes to Measure in Clinical Trials in Children

  • Ian Sinha mail,

    To whom correspondence should be addressed. E-mail: i.sinha@liv.ac.uk

    Affiliation: Institute of Child Health, University of Liverpool, Liverpool, United Kingdom

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  • Leanne Jones,

    Affiliation: Institute of Child Health, University of Liverpool, Liverpool, United Kingdom

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  • Rosalind L Smyth,

    Affiliation: Institute of Child Health, University of Liverpool, Liverpool, United Kingdom

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  • Paula R Williamson

    Affiliation: Centre for Medical Statistics and Health Evaluation, University of Liverpool, Liverpool, United Kingdom

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  • Published: April 29, 2008
  • DOI: 10.1371/journal.pmed.0050096

About the Authors

Ian Sinha, Leanne Jones, Rosalind L Smyth
Institute of Child Health, University of Liverpool, Liverpool, United Kingdom
Paula R Williamson
Centre for Medical Statistics and Health Evaluation, University of Liverpool, Liverpool, United Kingdom

Corresponding Author

Email: i.sinha@liv.ac.uk

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

IS, RLS, and PRW designed the study protocol and search strategy. IS and LJ identified the relevant studies from the search results. IS and LJ extracted data, which were checked by PRW and RLS. IS, LJ, RLS, and PRW were involved in data analysis. IS prepared the initial manuscript. IS, RLS, and PRW were all substantially involved in the revision of this manuscript. All authors checked the final manuscript before submission.