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Research Article

MMP1 and MMP7 as Potential Peripheral Blood Biomarkers in Idiopathic Pulmonary Fibrosis

  • Ivan O Rosas equal contributor,

    equal contributor Contributed equally to this work with: Ivan O Rosas, Thomas J Richards

    Affiliation: Dorothy P. and Richard P. Simmons Center for Interstitial Lung Diseases, Division of Pulmonary, Allergy and Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America

    X
  • Thomas J Richards equal contributor,

    equal contributor Contributed equally to this work with: Ivan O Rosas, Thomas J Richards

    Affiliation: Dorothy P. and Richard P. Simmons Center for Interstitial Lung Diseases, Division of Pulmonary, Allergy and Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America

    X
  • Kazuhisa Konishi,

    Affiliation: Dorothy P. and Richard P. Simmons Center for Interstitial Lung Diseases, Division of Pulmonary, Allergy and Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America

    X
  • Yingze Zhang,

    Affiliation: Dorothy P. and Richard P. Simmons Center for Interstitial Lung Diseases, Division of Pulmonary, Allergy and Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America

    X
  • Kevin Gibson,

    Affiliation: Dorothy P. and Richard P. Simmons Center for Interstitial Lung Diseases, Division of Pulmonary, Allergy and Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America

    X
  • Anna E Lokshin,

    Affiliations: Division of Hematology/Oncology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America, University of Pittsburgh Cancer Institute, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America

    X
  • Kathleen O Lindell,

    Affiliation: Dorothy P. and Richard P. Simmons Center for Interstitial Lung Diseases, Division of Pulmonary, Allergy and Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America

    X
  • Jose Cisneros,

    Affiliation: Instituto Nacional de Enfermedades Respiratorias, México DF, México

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  • Sandra D MacDonald,

    Affiliation: Pulmonary-Critical Care Medicine Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland, United States of America

    X
  • Annie Pardo,

    Affiliation: Facultad de Ciencias, Universidad Nacional Autónoma de México, México, Mexico

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  • Frank Sciurba,

    Affiliation: Dorothy P. and Richard P. Simmons Center for Interstitial Lung Diseases, Division of Pulmonary, Allergy and Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America

    X
  • James Dauber,

    Affiliation: Dorothy P. and Richard P. Simmons Center for Interstitial Lung Diseases, Division of Pulmonary, Allergy and Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America

    X
  • Moises Selman mail,

    To whom correspondence should be addressed. E-mail: kaminskin@upmc.edu (NK); gochuicb@mail.nih.gov (BRG); moiselman@salud.gob.mx (MS).

    Affiliation: Instituto Nacional de Enfermedades Respiratorias, México DF, México

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  • Bernadette R Gochuico mail,

    To whom correspondence should be addressed. E-mail: kaminskin@upmc.edu (NK); gochuicb@mail.nih.gov (BRG); moiselman@salud.gob.mx (MS).

    Affiliation: Pulmonary-Critical Care Medicine Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland, United States of America

    X
  • Naftali Kaminski mail

    To whom correspondence should be addressed. E-mail: kaminskin@upmc.edu (NK); gochuicb@mail.nih.gov (BRG); moiselman@salud.gob.mx (MS).

    Affiliation: Dorothy P. and Richard P. Simmons Center for Interstitial Lung Diseases, Division of Pulmonary, Allergy and Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America

    X
  • Published: April 29, 2008
  • DOI: 10.1371/journal.pmed.0050093

About the Authors

Ivan O Rosas, Thomas J Richards, Kazuhisa Konishi, Yingze Zhang, Kevin Gibson, Kathleen O Lindell, Frank Sciurba, James Dauber, Naftali Kaminski
Dorothy P. and Richard P. Simmons Center for Interstitial Lung Diseases, Division of Pulmonary, Allergy and Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America
Anna E Lokshin
Division of Hematology/Oncology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America
Anna E Lokshin
University of Pittsburgh Cancer Institute, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America
Jose Cisneros, Moises Selman
Instituto Nacional de Enfermedades Respiratorias, México DF, México
Sandra D MacDonald, Bernadette R Gochuico
Pulmonary-Critical Care Medicine Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland, United States of America
Annie Pardo
Facultad de Ciencias, Universidad Nacional Autónoma de México, México, Mexico

Corresponding Authors

Competing Interests

NK is a recipient of investigator initiated research grants from Biogen Idec and from Centocor for genomic and proteomic biomarker discovery and validation. Data presented in this paper were not funded by any of these grants. FS, as a consultant, has received less than $10,000 from GlaxoSmithKline (GSK) and Astra-Zeneca. All other authors declared no competing interests.

Author Contributions

IOR contributed to recruitment and analysis of the validation cohort, data analysis, conceptualization and design of the study, data analysis, and manuscript preparation. TJR contributed to project conceptualization, data analysis, statistics, and writing of the initial draft of the paper. KK contributed to microarray data generation and analysis, conceptualization of the study, and manuscript generation. YZ contributed to sample collection and protocol development, data analysis, and manuscript generation. KG contributed to participant recruitment, diagnosis, and ascertainment of the sarcoidosis cohort as well as the derivation cohort, protocol development, planning of experiments, and manuscript preparation. AEL contributed to Luminex data generation including custom assays and data analysis. KOL contributed to participant recruitment and diagnosis ascertainment of the derivation cohort, protocol development, and manuscript preparation. JC contributed to participant recruitment and diagnosis ascertainment of the HP cohort, ELISA assays, data analysis, and manuscript preparation. SDM contributed to participant recruitment and diagnosis ascertainment of the validation cohort, protocol development, and manuscript preparation. AP contributed to data analysis and manuscript preparation. FS contributed to participant recruitment and diagnosis ascertainment of the COPD cohort, protocol development, and manuscript preparation. JD contributed to conceptualization of proposed studies, diagnosis ascertainment of the derivation cohort, data analysis, and manuscript preparation. MS contributed to participant recruitment and diagnosis ascertainment of all Mexican patient cohorts, planning of the study, preparation of early drafts, and manuscript development. BRG contributed to design and conceptualization of the research project, participant recruitment and diagnosis ascertainment of the validation cohort, protocol development, and manuscript preparation. NK contributed to design and conceptualization of the research project, analysis of all data including gene expression and protein measurements, paper writing, and manuscript submission.