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Research Article

Long-Term Interleukin-6 Levels and Subsequent Risk of Coronary Heart Disease: Two New Prospective Studies and a Systematic Review

  • John Danesh equal contributor mail,

    equal contributor Contributed equally to this work with: John Danesh, Stephen Kaptoge

    To whom correspondence should be addressed. E-mail: john.danesh@phpc.cam.ac.uk

    Affiliation: Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom

    X
  • Stephen Kaptoge equal contributor,

    equal contributor Contributed equally to this work with: John Danesh, Stephen Kaptoge

    Affiliation: Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom

    X
  • Andrea G Mann,

    Affiliation: Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom

    X
  • Nadeem Sarwar,

    Affiliation: Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom

    X
  • Angela Wood,

    Affiliation: Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom

    X
  • Sara B Angleman,

    Affiliation: Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom

    X
  • Frances Wensley,

    Affiliation: Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom

    X
  • Julian P. T Higgins,

    Affiliation: Medical Research Council Biostatistics Unit and Public Health Genetics Unit, Cambridge, United Kingdom

    X
  • Lucy Lennon,

    Affiliation: Department of Primary Care and Population Sciences, Royal Free University College London Medical School, London, United Kingdom

    X
  • Gudny Eiriksdottir,

    Affiliations: Icelandic Heart Association, Kopavogur, Iceland, University of Iceland, Kopavogur, Iceland

    X
  • Ann Rumley,

    Affiliation: Division of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, Scotland, United Kingdom

    X
  • Peter H Whincup,

    Affiliation: Division of Community Health Sciences, St George's, University of London, London, United Kingdom

    X
  • Gordon D. O Lowe,

    Affiliation: Division of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, Scotland, United Kingdom

    X
  • Vilmundur Gudnason

    Affiliations: Icelandic Heart Association, Kopavogur, Iceland, University of Iceland, Kopavogur, Iceland

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  • Published: April 08, 2008
  • DOI: 10.1371/journal.pmed.0050078

About the Authors

John Danesh, Stephen Kaptoge, Andrea G Mann, Nadeem Sarwar, Angela Wood, Sara B Angleman, Frances Wensley
Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom
Julian P. T Higgins
Medical Research Council Biostatistics Unit and Public Health Genetics Unit, Cambridge, United Kingdom
Lucy Lennon
Department of Primary Care and Population Sciences, Royal Free University College London Medical School, London, United Kingdom
Gudny Eiriksdottir, Vilmundur Gudnason
Icelandic Heart Association, Kopavogur, Iceland
Gudny Eiriksdottir, Vilmundur Gudnason
University of Iceland, Kopavogur, Iceland
Ann Rumley, Gordon D. O Lowe
Division of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, Scotland, United Kingdom
Peter H Whincup
Division of Community Health Sciences, St George's, University of London, London, United Kingdom

Corresponding Author

Email: john.danesh@phpc.cam.ac.uk

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

JD, PHW, and VG conceived and designed the current work. SK and FW analysed the data. JD and SK drafted the paper. JD, SK, NS, AW, SBA, FW, JPTH, GE, AR, PHW, GDOL, and VG contributed to the writing of the paper. SK, AGM, NS, FW, and JPTH conducted the systematic review. LL collected the follow-up data in the BRHS. AR and GDOL supervised IL-6 assays.