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Research Article

Statins Impair Antitumor Effects of Rituximab by Inducing Conformational Changes of CD20

  • Magdalena Winiarska,

    Affiliations: Department of Immunology, Center of Biostructure Research, the Medical University of Warsaw, Warsaw, Poland, Department of Laboratory Diagnostics and Clinical Immunology, the Medical University of Warsaw, Warsaw, Poland

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  • Jacek Bil,

    Affiliation: Department of Immunology, Center of Biostructure Research, the Medical University of Warsaw, Warsaw, Poland

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  • Ewa Wilczek,

    Affiliation: Department of Pathology, Center of Biostructure Research, the Medical University of Warsaw, Warsaw, Poland

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  • Grzegorz M Wilczynski,

    Affiliation: Laboratory of Molecular and Systemic Neuromorphology, Nencki Institute of Experimental Biology, Warsaw, Poland

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  • Malgorzata Lekka,

    Affiliation: Department of Applied Spectroscopy, The Henryk Niewodniczanski Institute of Nuclear Physics, Krakow, Poland

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  • Patrick J Engelberts,

    Affiliation: Genmab, Utrecht, The Netherlands

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  • Wendy J. M Mackus,

    Affiliation: Genmab, Utrecht, The Netherlands

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  • Elzbieta Gorska,

    Affiliation: Department of Laboratory Diagnostics and Clinical Immunology, the Medical University of Warsaw, Warsaw, Poland

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  • Lukasz Bojarski,

    Affiliation: Laboratory of Neurodegeneration, International Institute of Molecular and Cell Biology, Warsaw, Poland

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  • Tomasz Stoklosa,

    Affiliation: Department of Immunology, Center of Biostructure Research, the Medical University of Warsaw, Warsaw, Poland

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  • Dominika Nowis,

    Affiliation: Department of Immunology, Center of Biostructure Research, the Medical University of Warsaw, Warsaw, Poland

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  • Zuzanna Kurzaj,

    Affiliation: Department of Immunology, Center of Biostructure Research, the Medical University of Warsaw, Warsaw, Poland

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  • Marcin Makowski,

    Affiliation: Department of Immunology, Center of Biostructure Research, the Medical University of Warsaw, Warsaw, Poland

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  • Eliza Glodkowska,

    Affiliation: Department of Immunology, Center of Biostructure Research, the Medical University of Warsaw, Warsaw, Poland

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  • Tadeusz Issat,

    Affiliation: Department of Immunology, Center of Biostructure Research, the Medical University of Warsaw, Warsaw, Poland

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  • Piotr Mrowka,

    Affiliation: Department of Immunology, Center of Biostructure Research, the Medical University of Warsaw, Warsaw, Poland

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  • Witold Lasek,

    Affiliation: Department of Immunology, Center of Biostructure Research, the Medical University of Warsaw, Warsaw, Poland

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  • Anna Dabrowska-Iwanicka,

    Affiliation: Department of Lymphoproliferative Disease, Maria Sklodowska-Curie Memorial Cancer Center, Institute of Oncology, Warsaw, Poland

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  • Grzegorz W Basak,

    Affiliation: Department of Hematology, Oncology and Internal Diseases, the Medical University of Warsaw, Warsaw, Poland

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  • Maria Wasik,

    Affiliation: Department of Laboratory Diagnostics and Clinical Immunology, the Medical University of Warsaw, Warsaw, Poland

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  • Krzysztof Warzocha,

    Affiliation: Institute of Hematology and Transfusion Medicine, Warsaw, Poland

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  • Maciej Sinski,

    Affiliation: Department of Internal Diseases, Hypertension and Vascular Disease, the Medical University of Warsaw, Warsaw, Poland

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  • Zbigniew Gaciong,

    Affiliation: Department of Internal Diseases, Hypertension and Vascular Disease, the Medical University of Warsaw, Warsaw, Poland

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  • Marek Jakobisiak,

    Affiliation: Department of Immunology, Center of Biostructure Research, the Medical University of Warsaw, Warsaw, Poland

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  • Paul W. H. I Parren,

    Affiliation: Genmab, Utrecht, The Netherlands

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  • Jakub Golab mail

    To whom correspondence should be addressed. E-mail: jgolab@ib.amwaw.edu.pl

    Affiliation: Department of Immunology, Center of Biostructure Research, the Medical University of Warsaw, Warsaw, Poland

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  • Published: March 25, 2008
  • DOI: 10.1371/journal.pmed.0050064

About the Authors

Magdalena Winiarska, Jacek Bil, Tomasz Stoklosa, Dominika Nowis, Zuzanna Kurzaj, Marcin Makowski, Eliza Glodkowska, Tadeusz Issat, Piotr Mrowka, Witold Lasek, Marek Jakobisiak, Jakub Golab
Department of Immunology, Center of Biostructure Research, the Medical University of Warsaw, Warsaw, Poland
Magdalena Winiarska, Elzbieta Gorska, Maria Wasik
Department of Laboratory Diagnostics and Clinical Immunology, the Medical University of Warsaw, Warsaw, Poland
Ewa Wilczek
Department of Pathology, Center of Biostructure Research, the Medical University of Warsaw, Warsaw, Poland
Grzegorz M Wilczynski
Laboratory of Molecular and Systemic Neuromorphology, Nencki Institute of Experimental Biology, Warsaw, Poland
Malgorzata Lekka
Department of Applied Spectroscopy, The Henryk Niewodniczanski Institute of Nuclear Physics, Krakow, Poland
Patrick J Engelberts, Wendy J. M Mackus, Paul W. H. I Parren
Genmab, Utrecht, The Netherlands
Lukasz Bojarski
Laboratory of Neurodegeneration, International Institute of Molecular and Cell Biology, Warsaw, Poland
Anna Dabrowska-Iwanicka
Department of Lymphoproliferative Disease, Maria Sklodowska-Curie Memorial Cancer Center, Institute of Oncology, Warsaw, Poland
Grzegorz W Basak
Department of Hematology, Oncology and Internal Diseases, the Medical University of Warsaw, Warsaw, Poland
Krzysztof Warzocha
Institute of Hematology and Transfusion Medicine, Warsaw, Poland
Maciej Sinski, Zbigniew Gaciong
Department of Internal Diseases, Hypertension and Vascular Disease, the Medical University of Warsaw, Warsaw, Poland

Corresponding Author

Email: jgolab@ib.amwaw.edu.pl

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

MW, JB, EW, and DN designed the study, collected and analyzed the data, enrolled patients, and contributed to writing the paper. GMW, WJMM, E. Gorska, LB, E. Glodkowska, PM, and WL designed the study, collected and analyzed the data, and contributed to writing the paper. ML and TS collected and analyzed data and contributed to writing the paper. PJE collected and analyzed data. ZK designed the study and collected and analyzed the data. MM designed the study, collected data, and contributed to writing the paper. TI, ADI, MW, MJ, PWHIP, and JG designed the study, analyzed data, and contributed to writing the paper. GWB enrolled patients. KW enrolled patients and contributed to writing the paper. MS designed the study, collected data, enrolled patients, and contributed to writing the paper. ZG designed the study and contributed to writing the paper.