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Research Article

Aberrant Mucin Assembly in Mice Causes Endoplasmic Reticulum Stress and Spontaneous Inflammation Resembling Ulcerative Colitis

  • Chad K Heazlewood equal contributor,

    equal contributor Contributed equally to this work with: Chad K Heazlewood, Matthew C Cook, Rajaraman Eri

    Affiliation: Mucin and IBD Research Teams, Mucosal Diseases Program, Mater Medical Research Institute, and the University of Queensland, Aubigny Place, Mater Health Services, South Brisbane, Queensland, Australia

    X
  • Matthew C Cook equal contributor,

    equal contributor Contributed equally to this work with: Chad K Heazlewood, Matthew C Cook, Rajaraman Eri

    Affiliation: Immunology and Inflammation Group, Phenomix Australia, Acton, Australia

    ¤ Current address: Australian National University Medical School, Canberra, Australia

    X
  • Rajaraman Eri equal contributor,

    equal contributor Contributed equally to this work with: Chad K Heazlewood, Matthew C Cook, Rajaraman Eri

    Affiliation: Mucin and IBD Research Teams, Mucosal Diseases Program, Mater Medical Research Institute, and the University of Queensland, Aubigny Place, Mater Health Services, South Brisbane, Queensland, Australia

    X
  • Gareth R Price,

    Affiliation: Molecular Genetics Team, Mater Medical Research Institute, and the University of Queensland, Aubigny Place, Mater Health Services, South Brisbane, Queensland, Australia

    X
  • Sharyn B Tauro,

    Affiliation: Mucin and IBD Research Teams, Mucosal Diseases Program, Mater Medical Research Institute, and the University of Queensland, Aubigny Place, Mater Health Services, South Brisbane, Queensland, Australia

    X
  • Douglas Taupin,

    Affiliation: Gastroenterology Unit, Canberra Hospital, Woden, Australia

    X
  • David J Thornton,

    Affiliation: Wellcome Trust Centre for Cell Matrix Research, Faculty of Life Sciences, University of Manchester, Manchester, United Kingdom

    X
  • Chin Wen Png,

    Affiliation: Mucin and IBD Research Teams, Mucosal Diseases Program, Mater Medical Research Institute, and the University of Queensland, Aubigny Place, Mater Health Services, South Brisbane, Queensland, Australia

    X
  • Tanya L Crockford,

    Affiliation: Nuffield Dept of Clinical Medicine, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom

    X
  • Richard J Cornall,

    Affiliation: Nuffield Dept of Clinical Medicine, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom

    X
  • Rachel Adams,

    Affiliation: Mucin and IBD Research Teams, Mucosal Diseases Program, Mater Medical Research Institute, and the University of Queensland, Aubigny Place, Mater Health Services, South Brisbane, Queensland, Australia

    X
  • Masato Kato,

    Affiliation: Dendritic Cell Program, Mater Medical Research Institute, Aubigny Place, Mater Health Services, South Brisbane, Queensland, Australia

    X
  • Keats A Nelms,

    Affiliation: Immunology and Inflammation Group, Phenomix Australia, Acton, Australia

    ¤ Current address: Australian National University Medical School, Canberra, Australia

    X
  • Nancy A Hong,

    Affiliation: Phenomix Corporation, San Diego, California, United States of America

    X
  • Timothy H. J Florin,

    Affiliation: Mucin and IBD Research Teams, Mucosal Diseases Program, Mater Medical Research Institute, and the University of Queensland, Aubigny Place, Mater Health Services, South Brisbane, Queensland, Australia

    X
  • Christopher C Goodnow,

    Affiliation: Division of Immunology and Genetics and Australian Phenomics Facility, John Curtin School of Medical Research, The Australian National University, Canberra, Australia

    X
  • Michael A McGuckin mail

    To whom correspondence should be addressed. E-mail: mmcguckin@mmri.mater.org.au

    Affiliation: Mucin and IBD Research Teams, Mucosal Diseases Program, Mater Medical Research Institute, and the University of Queensland, Aubigny Place, Mater Health Services, South Brisbane, Queensland, Australia

    X
  • Published: March 04, 2008
  • DOI: 10.1371/journal.pmed.0050054

About the Authors

Chad K Heazlewood, Rajaraman Eri, Sharyn B Tauro, Chin Wen Png, Rachel Adams, Timothy H. J Florin, Michael A McGuckin
Mucin and IBD Research Teams, Mucosal Diseases Program, Mater Medical Research Institute, and the University of Queensland, Aubigny Place, Mater Health Services, South Brisbane, Queensland, Australia
Matthew C Cook, Keats A Nelms
Immunology and Inflammation Group, Phenomix Australia, Acton, Australia
Gareth R Price
Molecular Genetics Team, Mater Medical Research Institute, and the University of Queensland, Aubigny Place, Mater Health Services, South Brisbane, Queensland, Australia
Douglas Taupin
Gastroenterology Unit, Canberra Hospital, Woden, Australia
David J Thornton
Wellcome Trust Centre for Cell Matrix Research, Faculty of Life Sciences, University of Manchester, Manchester, United Kingdom
Tanya L Crockford, Richard J Cornall
Nuffield Dept of Clinical Medicine, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom
Masato Kato
Dendritic Cell Program, Mater Medical Research Institute, Aubigny Place, Mater Health Services, South Brisbane, Queensland, Australia
Nancy A Hong
Phenomix Corporation, San Diego, California, United States of America
Christopher C Goodnow
Division of Immunology and Genetics and Australian Phenomics Facility, John Curtin School of Medical Research, The Australian National University, Canberra, Australia

Corresponding Author

Email: mmcguckin@mmri.mater.org.au

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

CKH, MCC, RE, GRP, SBT, DT, DJT, CWP, TLC, RA, MK, KAN, NAH, and MAM planned and conducted experiments, analysed data, and contributed to preparation of the manuscript. RJC, THJF, and CCG were involved in experimental planning, data analysis and preparation of the manuscript.