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Research Article

Global Transcript Profiles of Fat in Monozygotic Twins Discordant for BMI: Pathways behind Acquired Obesity

  • Kirsi H Pietiläinen equal contributor,

    equal contributor Contributed equally to this work with: Kirsi H Pietiläinen, Jussi Naukkarinen

    Affiliations: Obesity Research Unit, Department of Psychiatry, Helsinki University Central Hospital, Helsinki, Finland, Department of Medicine, Division of Diabetes, Helsinki University Central Hospital, Helsinki, Finland, Finnish Twin Cohort Study, Department of Public Health, University of Helsinki, Helsinki, Finland

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  • Jussi Naukkarinen equal contributor,

    equal contributor Contributed equally to this work with: Kirsi H Pietiläinen, Jussi Naukkarinen

    Affiliations: Department of Molecular Medicine, National Public Health Institute, Helsinki, Finland, Department of Medical Genetics and Research Program of Molecular Medicine, University of Helsinki, Finland

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  • Aila Rissanen,

    Affiliation: Obesity Research Unit, Department of Psychiatry, Helsinki University Central Hospital, Helsinki, Finland

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  • Juha Saharinen,

    Affiliations: Department of Molecular Medicine, National Public Health Institute, Helsinki, Finland, Department of Medical Genetics and Research Program of Molecular Medicine, University of Helsinki, Finland

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  • Pekka Ellonen,

    Affiliations: Department of Molecular Medicine, National Public Health Institute, Helsinki, Finland, Department of Medical Genetics and Research Program of Molecular Medicine, University of Helsinki, Finland

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  • Heli Keränen,

    Affiliations: Department of Molecular Medicine, National Public Health Institute, Helsinki, Finland, Department of Medical Genetics and Research Program of Molecular Medicine, University of Helsinki, Finland

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  • Anu Suomalainen,

    Affiliation: Research Program of Molecular Neurology and Department of Neurology, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland

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  • Alexandra Götz,

    Affiliation: Research Program of Molecular Neurology and Department of Neurology, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland

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  • Tapani Suortti,

    Affiliation: VTT Technical Research Centre of Finland, Espoo, Finland

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  • Hannele Yki-Järvinen,

    Affiliation: Department of Medicine, Division of Diabetes, Helsinki University Central Hospital, Helsinki, Finland

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  • Matej Orešič,

    Affiliation: VTT Technical Research Centre of Finland, Espoo, Finland

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  • Jaakko Kaprio,

    Affiliations: Finnish Twin Cohort Study, Department of Public Health, University of Helsinki, Helsinki, Finland, Department of Mental Health and Alcohol Research, National Public Health Institute, Helsinki, Finland

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  • Leena Peltonen mail

    To whom correspondence should be addressed. E-mail: leena.peltonen@ktl.fi

    Affiliations: Department of Molecular Medicine, National Public Health Institute, Helsinki, Finland, Department of Medical Genetics and Research Program of Molecular Medicine, University of Helsinki, Finland, The Wellcome Trust Sanger Institute, Cambridge, United Kingdom, Broad Institute, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America

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  • Published: March 11, 2008
  • DOI: 10.1371/journal.pmed.0050051

About the Authors

Kirsi H Pietiläinen, Aila Rissanen
Obesity Research Unit, Department of Psychiatry, Helsinki University Central Hospital, Helsinki, Finland
Kirsi H Pietiläinen, Hannele Yki-Järvinen
Department of Medicine, Division of Diabetes, Helsinki University Central Hospital, Helsinki, Finland
Kirsi H Pietiläinen, Jaakko Kaprio
Finnish Twin Cohort Study, Department of Public Health, University of Helsinki, Helsinki, Finland
Jussi Naukkarinen, Juha Saharinen, Pekka Ellonen, Heli Keränen, Leena Peltonen
Department of Molecular Medicine, National Public Health Institute, Helsinki, Finland
Jussi Naukkarinen, Juha Saharinen, Pekka Ellonen, Heli Keränen, Leena Peltonen
Department of Medical Genetics and Research Program of Molecular Medicine, University of Helsinki, Finland
Anu Suomalainen, Alexandra Götz
Research Program of Molecular Neurology and Department of Neurology, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland
Tapani Suortti, Matej Orešič
VTT Technical Research Centre of Finland, Espoo, Finland
Jaakko Kaprio
Department of Mental Health and Alcohol Research, National Public Health Institute, Helsinki, Finland
Leena Peltonen
The Wellcome Trust Sanger Institute, Cambridge, United Kingdom
Leena Peltonen
Broad Institute, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America

Corresponding Author

Email: leena.peltonen@ktl.fi

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

AR initiated the concept of the study and KHP, AR, HYJ, JK, and LP designed it. JK was responsible for collecting the study base from which the discordant pairs were selected. KHP conducted the trial and AR, HYJ, and JK supervised its progression. LP carried the overall responsibility of the study design of genome-wide transcription and pathway analyses conducted by JN and JS. AS and LP supervised the mitochondrial sequence analyses performed by PE, HK, and AG. TS and MO analyzed serum BCAAs and their ketoacids. KHP and JS performed the statistical analyses. All authors contributed to interpretation of the data and KHP, JN, AR, MO, and LP, wrote the manuscript.