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Research Article

An Antibiotic-Responsive Mouse Model of Fulminant Ulcerative Colitis

  • Silvia S Kang,

    Affiliation: Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri, United States of America

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  • Seth M Bloom,

    Affiliation: Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri, United States of America

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  • Lyse A Norian,

    Affiliation: Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri, United States of America

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  • Michael J Geske,

    Affiliation: Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri, United States of America

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  • Richard A Flavell,

    Affiliations: Section of Immunobiology, Yale University School of Medicine, New Haven, Connecticut, United States of America, Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, Connecticut, United States of America

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  • Thaddeus S Stappenbeck mail,

    To whom correspondence should be addressed. E-mail: stappenb@wustl.edu (TSS); pallen@wustl.edu (PMA)

    Affiliation: Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri, United States of America

    These authors are joint senior authors on this work.

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  • Paul M Allen mail

    To whom correspondence should be addressed. E-mail: stappenb@wustl.edu (TSS); pallen@wustl.edu (PMA)

    Affiliation: Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri, United States of America

    These authors are joint senior authors on this work.

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  • Published: March 04, 2008
  • DOI: 10.1371/journal.pmed.0050041

About the Authors

Silvia S Kang, Seth M Bloom, Lyse A Norian, Michael J Geske, Thaddeus S Stappenbeck, Paul M Allen
Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri, United States of America
Richard A Flavell
Section of Immunobiology, Yale University School of Medicine, New Haven, Connecticut, United States of America
Richard A Flavell
Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, Connecticut, United States of America

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

SSK, SMB, TSS, and PMA designed the study, analyzed the data, and wrote the paper. SSK, SMB, and LAN did the experiments. MJG performed the statistical analysis. RAF provided the dnTGFβRII mice and the expertise in their use.