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Research Article

An Erythroid Differentiation Signature Predicts Response to Lenalidomide in Myelodysplastic Syndrome

  • Benjamin L Ebert equal contributor,

    equal contributor Contributed equally to this work with: Benjamin L Ebert, Naomi Galili

    Affiliations: Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, United States of America, Brigham and Women's Hospital, Department of Medicine, Boston, Massachusetts, United States of America

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  • Naomi Galili equal contributor,

    equal contributor Contributed equally to this work with: Benjamin L Ebert, Naomi Galili

    Affiliation: St. Vincent's Comprehensive Cancer Center, New York, New York, United States of America

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  • Pablo Tamayo,

    Affiliation: Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America

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  • Jocelyn Bosco,

    Affiliations: Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, United States of America

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  • Raymond Mak,

    Affiliations: Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, United States of America

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  • Jennifer Pretz,

    Affiliations: Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, United States of America

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  • Shyam Tanguturi,

    Affiliation: Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America

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  • Christine Ladd-Acosta,

    Affiliation: Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America

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  • Richard Stone,

    Affiliations: Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, United States of America, Brigham and Women's Hospital, Department of Medicine, Boston, Massachusetts, United States of America

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  • Todd R Golub,

    Affiliations: Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, United States of America, Childrens's Hospital, Boston, Massachusetts, United States of America, Howard Hughes Medical Institute, Chevy Chase, Maryland, United States of America

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  • Azra Raza mail

    To whom correspondence should be addressed. E-mail: araza@aptiumoncology.com

    Affiliation: St. Vincent's Comprehensive Cancer Center, New York, New York, United States of America

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  • Published: February 12, 2008
  • DOI: 10.1371/journal.pmed.0050035

About the Authors

Benjamin L Ebert, Pablo Tamayo, Jocelyn Bosco, Raymond Mak, Jennifer Pretz, Shyam Tanguturi, Christine Ladd-Acosta, Todd R Golub
Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America
Benjamin L Ebert, Jocelyn Bosco, Raymond Mak, Jennifer Pretz, Richard Stone, Todd R Golub
Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, United States of America
Benjamin L Ebert, Richard Stone
Brigham and Women's Hospital, Department of Medicine, Boston, Massachusetts, United States of America
Naomi Galili, Azra Raza
St. Vincent's Comprehensive Cancer Center, New York, New York, United States of America
Todd R Golub
Childrens's Hospital, Boston, Massachusetts, United States of America
Todd R Golub
Howard Hughes Medical Institute, Chevy Chase, Maryland, United States of America

Corresponding Author

Email: araza@aptiumoncology.com

Competing Interests

Azra Raza and Richard Stone are involved with a speaker's bureau for Celgene.

Author Contributions

BLE designed research, analyzed data, and wrote the manuscript. NG designed research and collected data. PT analyzed data. JB, RM, JP, ST, and CL performed experiments. RS contributed vital samples. TRG supervised all aspects of the work. AR supervised all aspects of the work and contributed vital samples.