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Research Article

A Collaborative Epidemiological Investigation into the Criminal Fake Artesunate Trade in South East Asia

  • Paul N Newton mail,

    To whom correspondence should be addressed. E-mail: paul@tropmedres.ac (PNN) and j.newton@interpol.int (JN)

    Affiliations: Centre for Tropical Medicine, Nuffield Department of Clinical Medicine, University of Oxford, Churchill Hospital, Oxford, United Kingdom, Wellcome Trust—Mahosot Hospital-Oxford Tropical Medicine Research Collaboration, Mahosot Hospital, Vientiane, Lao People's Democratic Republic

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  • Facundo M Fernández,

    Affiliation: School of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, Georgia, United States of America

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  • Aline Plançon,

    Affiliation: Intellectual Property Crime Unit, International Criminal Police Organization (INTERPOL), Lyon, France

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  • Dallas C Mildenhall,

    Affiliation: GNS Science, Lower Hutt, New Zealand

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  • Michael D Green,

    Affiliation: Division of Parasitic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America

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  • Li Ziyong,

    Affiliation: Intellectual Property Division, Economic Crime Investigation Department, Ministry of Public Security, Beijing, People's Republic of China

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  • Eva Maria Christophel,

    Affiliation: Western Pacific Regional Office of the World Health Organization, Manila, The Philippines

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  • Souly Phanouvong,

    Affiliation: United States Pharmacopeia, Rockville, Maryland, United States of America

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  • Stephen Howells,

    Affiliation: Therapeutic Goods Administration, Government of Australia, Symonston, Canberra, Australia

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  • Eric McIntosh,

    Affiliation: Therapeutic Goods Administration, Government of Australia, Symonston, Canberra, Australia

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  • Paul Laurin,

    Affiliation: Royal Canadian Mounted Police Forensic Laboratory Services, National Anti- Counterfeiting Bureau, Ottawa, Ontario, Canada

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  • Nancy Blum,

    Affiliation: United States Pharmacopeia, Rockville, Maryland, United States of America

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  • Christina Y Hampton,

    Affiliation: School of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, Georgia, United States of America

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  • Kevin Faure,

    Affiliation: GNS Science, Lower Hutt, New Zealand

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  • Leonard Nyadong,

    Affiliation: School of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, Georgia, United States of America

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  • C. W. Ray Soong,

    Affiliation: GNS Science, Lower Hutt, New Zealand

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  • Budiono Santoso,

    Affiliation: Western Pacific Regional Office of the World Health Organization, Manila, The Philippines

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  • Wang Zhiguang,

    Affiliation: Intellectual Property Division, Economic Crime Investigation Department, Ministry of Public Security, Beijing, People's Republic of China

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  • John Newton mail,

    To whom correspondence should be addressed. E-mail: paul@tropmedres.ac (PNN) and j.newton@interpol.int (JN)

    Affiliation: Intellectual Property Crime Unit, International Criminal Police Organization (INTERPOL), Lyon, France

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  • Kevin Palmer

    Affiliation: Western Pacific Regional Office of the World Health Organization, Manila, The Philippines

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  • Published: February 12, 2008
  • DOI: 10.1371/journal.pmed.0050032

About the Authors

Paul N Newton
Centre for Tropical Medicine, Nuffield Department of Clinical Medicine, University of Oxford, Churchill Hospital, Oxford, United Kingdom
Paul N Newton
Wellcome Trust—Mahosot Hospital-Oxford Tropical Medicine Research Collaboration, Mahosot Hospital, Vientiane, Lao People's Democratic Republic
Facundo M Fernández, Christina Y Hampton, Leonard Nyadong
School of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, Georgia, United States of America
Aline Plançon, John Newton
Intellectual Property Crime Unit, International Criminal Police Organization (INTERPOL), Lyon, France
Dallas C Mildenhall, Kevin Faure, C. W. Ray Soong
GNS Science, Lower Hutt, New Zealand
Michael D Green
Division of Parasitic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America
Li Ziyong, Wang Zhiguang
Intellectual Property Division, Economic Crime Investigation Department, Ministry of Public Security, Beijing, People's Republic of China
Eva Maria Christophel, Budiono Santoso, Kevin Palmer
Western Pacific Regional Office of the World Health Organization, Manila, The Philippines
Souly Phanouvong, Nancy Blum
United States Pharmacopeia, Rockville, Maryland, United States of America
Stephen Howells, Eric McIntosh
Therapeutic Goods Administration, Government of Australia, Symonston, Canberra, Australia
Paul Laurin
Royal Canadian Mounted Police Forensic Laboratory Services, National Anti- Counterfeiting Bureau, Ottawa, Ontario, Canada

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

PNN planned the study, analyzed data, and wrote the first draft. FMF developed mass spectrometry methodology, supervised mass spectrometry analysis, analyzed data, and edited the draft. AP coordinated INTERPOL liaison, performed criminal analysis, and edited the draft. DCM supervised botanical analysis and edited the draft. MDG supervised HPLC analysis and edited the draft. LZ supervised criminal investigation in China and edited the draft. EMC coordinated the WPRO liaison, analyzed the data, and edited the draft. SP, coordinated the USP liaison, analyzed data, and edited the draft. SH and EM planned the study, coordinated the TGA liaison, analyzed data, and edited the draft. PL performed packaging analysis and edited the draft. NB, BS, and KP planned the study, analyzed data, and edited the draft. CYH performed DART mass spectrometry analysis and edited the draft. KF performed stable isotope analysis and edited the draft. LN performed DESI mass spectrometry analysis and edited the draft. CWRS performed XRD analysis and edited the draft. WZ supervised criminal investigation in China and edited the draft. JN chaired the Jupiter working group, planned the study, and edited the draft.