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Research Article

Prevention of Rectal SHIV Transmission in Macaques by Daily or Intermittent Prophylaxis with Emtricitabine and Tenofovir

  • J. Gerardo García-Lerma mail,

    To whom correspondence should be addressed. E-mail: GGarcia-Lerma@cdc.gov (JGGL); WHeneine@cdc.gov (WH)

    Affiliation: Division of HIV/AIDS Prevention, National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America

    X
  • Ron A Otten,

    Affiliation: Division of HIV/AIDS Prevention, National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America

    X
  • Shoukat H Qari,

    Affiliation: Division of HIV/AIDS Prevention, National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America

    X
  • Eddie Jackson,

    Affiliation: Division of Scientific Resources, National Center for Preparedness, Detection, and Control of Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America

    X
  • Mian-er Cong,

    Affiliation: Division of HIV/AIDS Prevention, National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America

    X
  • Silvina Masciotra,

    Affiliation: Division of HIV/AIDS Prevention, National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America

    X
  • Wei Luo,

    Affiliation: Division of HIV/AIDS Prevention, National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America

    X
  • Caryn Kim,

    Affiliation: Division of HIV/AIDS Prevention, National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America

    X
  • Debra R Adams,

    Affiliation: Division of HIV/AIDS Prevention, National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America

    X
  • Michael Monsour,

    Affiliation: Division of HIV/AIDS Prevention, National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America

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  • Jonathan Lipscomb,

    Affiliation: Division of HIV/AIDS Prevention, National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America

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  • Jeffrey A Johnson,

    Affiliation: Division of HIV/AIDS Prevention, National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America

    X
  • David Delinsky,

    Affiliation: Emory University School of Medicine/Veterans Affairs Medical Center, Decatur, Georgia, United States of America

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  • Raymond F Schinazi,

    Affiliation: Emory University School of Medicine/Veterans Affairs Medical Center, Decatur, Georgia, United States of America

    X
  • Robert Janssen,

    Affiliation: Division of HIV/AIDS Prevention, National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America

    X
  • Thomas M Folks,

    Affiliation: Division of HIV/AIDS Prevention, National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America

    X
  • Walid Heneine mail

    To whom correspondence should be addressed. E-mail: GGarcia-Lerma@cdc.gov (JGGL); WHeneine@cdc.gov (WH)

    Affiliation: Division of HIV/AIDS Prevention, National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America

    X
  • Published: February 05, 2008
  • DOI: 10.1371/journal.pmed.0050028

About the Authors

J. Gerardo García-Lerma, Ron A Otten, Shoukat H Qari, Mian-er Cong, Silvina Masciotra, Wei Luo, Caryn Kim, Debra R Adams, Michael Monsour, Jonathan Lipscomb, Jeffrey A Johnson, Robert Janssen, Thomas M Folks, Walid Heneine
Division of HIV/AIDS Prevention, National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America
Eddie Jackson
Division of Scientific Resources, National Center for Preparedness, Detection, and Control of Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America
David Delinsky, Raymond F Schinazi
Emory University School of Medicine/Veterans Affairs Medical Center, Decatur, Georgia, United States of America

Corresponding Authors

Competing Interests

Authors JGGL, RAO, RJ, TMF, and WH are named in a US Government patent application related to methods for HIV prophylaxis.

Author Contributions

JGGL and WH were the principal investigators of the study and drafted the manuscript. TMF, RAO, and RJ contributed substantially to study conception and design and critically reviewed the manuscript. SQ, EJ, MC, SM, WL, CK, DRA, JL, JAJ, DD, and RFS contributed to data collection and analysis. MM performed statistical analysis.