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Research Article

Functions of Paracrine PDGF Signaling in the Proangiogenic Tumor Stroma Revealed by Pharmacological Targeting

  • Kristian Pietras mail,

    To whom correspondence should be addressed. E-mail: kristian.pietras@licr.ki.se (KP); dh@biochem.ucsf.edu (DH)

    Affiliations: Department of Biochemistry and Biophysics, Diabetes Center and Comprehensive Cancer Center, University of California San Francisco, San Francisco, California, United States of America, Ludwig Institute for Cancer Research, Karolinska Institutet, Stockholm, Sweden

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  • Jessica Pahler,

    Affiliation: Department of Biochemistry and Biophysics, Diabetes Center and Comprehensive Cancer Center, University of California San Francisco, San Francisco, California, United States of America

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  • Gabriele Bergers,

    Affiliation: Department of Neurosurgery, University of California San Franciso, San Francisco, California, United States of America

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  • Douglas Hanahan mail

    To whom correspondence should be addressed. E-mail: kristian.pietras@licr.ki.se (KP); dh@biochem.ucsf.edu (DH)

    Affiliation: Department of Biochemistry and Biophysics, Diabetes Center and Comprehensive Cancer Center, University of California San Francisco, San Francisco, California, United States of America

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  • Published: January 29, 2008
  • DOI: 10.1371/journal.pmed.0050019

About the Authors

Kristian Pietras, Jessica Pahler, Douglas Hanahan
Department of Biochemistry and Biophysics, Diabetes Center and Comprehensive Cancer Center, University of California San Francisco, San Francisco, California, United States of America
Kristian Pietras
Ludwig Institute for Cancer Research, Karolinska Institutet, Stockholm, Sweden
Gabriele Bergers
Department of Neurosurgery, University of California San Franciso, San Francisco, California, United States of America

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

KP and DH designed the study. KP and JP performed research. KP, GB, and DH analyzed the data and contributed to writing the paper. GB contributed new reagents.