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Research Article

Antiretroviral Pre-exposure Prophylaxis Prevents Vaginal Transmission of HIV-1 in Humanized BLT Mice

  • Paul W Denton,

    Affiliation: Department of Internal Medicine, Division of Infectious Diseases, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas, United States of America

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  • Jacob D Estes,

    Affiliation: Department of Microbiology, Medical School, University of Minnesota, Minneapolis, Minnesota, United States of America

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  • Zhifeng Sun,

    Affiliation: Department of Internal Medicine, Division of Infectious Diseases, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas, United States of America

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  • Florence A Othieno,

    Affiliation: Department of Internal Medicine, Division of Infectious Diseases, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas, United States of America

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  • Bangdong L Wei,

    Affiliation: Department of Internal Medicine, Division of Infectious Diseases, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas, United States of America

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  • Anja K Wege,

    Affiliation: Department of Internal Medicine, Division of Infectious Diseases, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas, United States of America

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  • Daniel A Powell,

    Affiliation: Department of Internal Medicine, Division of Infectious Diseases, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas, United States of America

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  • Deborah Payne,

    Affiliation: Department of Pathology, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas, United States of America

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  • Ashley T Haase,

    Affiliation: Department of Microbiology, Medical School, University of Minnesota, Minneapolis, Minnesota, United States of America

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  • J. Victor Garcia mail

    To whom correspondence should be addressed. E-mail: victor.garcia@utsouthwestern.edu

    Affiliation: Department of Internal Medicine, Division of Infectious Diseases, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas, United States of America

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  • Published: January 15, 2008
  • DOI: 10.1371/journal.pmed.0050016

About the Authors

Paul W Denton, Zhifeng Sun, Florence A Othieno, Bangdong L Wei, Anja K Wege, Daniel A Powell, J. Victor Garcia
Department of Internal Medicine, Division of Infectious Diseases, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas, United States of America
Jacob D Estes, Ashley T Haase
Department of Microbiology, Medical School, University of Minnesota, Minneapolis, Minnesota, United States of America
Deborah Payne
Department of Pathology, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas, United States of America

Corresponding Author

Email: victor.garcia@utsouthwestern.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

PWD, JDE, ATH, and JVG planned the project, designed experiments, carried out experiments, analyzed data, and wrote the manuscript. DP designed the analysis of viral loads in humanized mice and supervised their performance. ZS, FAO, BLW, AKW, and DAP carried out experiments and collected, analyzed, and discussed data.