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Research Article

Neovascular Age-Related Macular Degeneration Risk Based on CFH, LOC387715/HTRA1, and Smoking

  • Anne E Hughes mail,

    To whom correspondence should be addressed. E-mail: A.Hughes@qub.ac.uk

    Affiliation: Department of Medical Genetics, Queen's University Belfast, Belfast, United Kingdom

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  • Nick Orr,

    Affiliation: Department of Medical Genetics, Queen's University Belfast, Belfast, United Kingdom

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  • Chris Patterson,

    Affiliation: Department of Epidemiology and Public Health, Queen's University Belfast, Belfast, United Kingdom

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  • Hossein Esfandiary,

    Affiliation: Department of Medical Genetics, Queen's University Belfast, Belfast, United Kingdom

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  • Ruth Hogg,

    Affiliation: Centre for Vision Science and Vascular Biology, Queen's University Belfast, Belfast, United Kingdom

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  • Vivienne McConnell,

    Affiliation: Department of Medical Genetics, Queen's University Belfast, Belfast, United Kingdom

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  • Giuliana Silvestri,

    Affiliation: Centre for Vision Science and Vascular Biology, Queen's University Belfast, Belfast, United Kingdom

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  • Usha Chakravarthy

    Affiliation: Centre for Vision Science and Vascular Biology, Queen's University Belfast, Belfast, United Kingdom

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  • Published: December 27, 2007
  • DOI: 10.1371/journal.pmed.0040355

About the Authors

Anne E Hughes, Nick Orr, Hossein Esfandiary, Vivienne McConnell
Department of Medical Genetics, Queen's University Belfast, Belfast, United Kingdom
Chris Patterson
Department of Epidemiology and Public Health, Queen's University Belfast, Belfast, United Kingdom
Ruth Hogg, Giuliana Silvestri, Usha Chakravarthy
Centre for Vision Science and Vascular Biology, Queen's University Belfast, Belfast, United Kingdom

Corresponding Author

Email: A.Hughes@qub.ac.uk

Competing Interests

Queen's University Belfast holds a patent titled “Protection against and treatment of Age-Related Macular Degeneration.”

Author Contributions

AEH was the principal investigator of this study, had full access to all of the data, and takes responsibility for the integrity of the data and the accuracy of the data analysis and for the decision to submit this paper for publication. NO and HE assisted in the design and NO also assisted in implementation and data analysis. CP performed logistic regression and further statistical analysis. All AMD patients were under the supervision of GS and UC, who phenotyped and took patient samples and smoking history with the assistance of VMcC. RH provided smoking status of some patients and assisted with extraction of DNA. AEH wrote the manuscript, which has been approved by all authors.