Advertisement
Research Article

Targeting of Interferon-Beta to Produce a Specific, Multi-Mechanistic Oncolytic Vaccinia Virus

  • David H Kirn,

    Affiliations: Jennerex Biotherapeutics, San Francisco, California, United States of America, Clinical Pharmacology, University of Oxford, Oxford, United Kingdom

    X
  • Yaohe Wang,

    Affiliation: Cancer Research UK Molecular Oncology Centre, Queen Mary's School of Medicine and Dentistry, Charterhouse Square, London, United Kingdom

    X
  • Fabrice Le Boeuf,

    Affiliation: Ottawa Health Research Institute, Ottawa, Ontario, Canada

    X
  • John Bell,

    Affiliation: Ottawa Health Research Institute, Ottawa, Ontario, Canada

    X
  • Steve H Thorne mail

    To whom correspondence should be addressed. E-mail: thornesh@upmc.edu

    Affiliations: Jennerex Biotherapeutics, San Francisco, California, United States of America, Department of Pediatrics and Bio-X Program, Stanford University, Stanford, California, United States of America

    ¤ Current address: Division of Surgical Oncology, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America

    X
  • Published: December 27, 2007
  • DOI: 10.1371/journal.pmed.0040353

About the Authors

David H Kirn, Steve H Thorne
Jennerex Biotherapeutics, San Francisco, California, United States of America
David H Kirn
Clinical Pharmacology, University of Oxford, Oxford, United Kingdom
Yaohe Wang
Cancer Research UK Molecular Oncology Centre, Queen Mary's School of Medicine and Dentistry, Charterhouse Square, London, United Kingdom
Fabrice Le Boeuf, John Bell
Ottawa Health Research Institute, Ottawa, Ontario, Canada
Steve H Thorne
Department of Pediatrics and Bio-X Program, Stanford University, Stanford, California, United States of America

Corresponding Author

Email: thornesh@upmc.edu

Competing Interests

DHK, FLB, JB, and SHT all declare a financial interest in Jennerex Biotherapeutics, Inc. SHT is a shareholder; FLB receives a portion of his salary from Jennerex, JB sits on the Board of Directors, and DHK is President and CEO of Jennerex. JB is Director of the Canadian Oncolytic Virus Consortium and hold grants from the National Cancer Institute of Canada directed towards the discovery and, ultimately, clinical testing of oncolytic viruses. JB's host institute (Ottawa Health Research Institute [OHRI]) is an equity holder in Jennerex ULC.

Author Contributions

DHK, FLB, JB, and SHT designed the study. DHK, YW, FLB, and SHT analyzed the data. DHK, JB, and SHT contributed to writing the paper.