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Research Article

Assessment of Recent HIV-1 Infection by a Line Immunoassay for HIV-1/2 Confirmation

  • Jörg Schüpbach mail,

    To whom correspondence should be addressed. E-mail: jorg.schupbach@access.uzh.ch

    Affiliation: University of Zurich, Swiss National Center for Retroviruses, Zurich, Switzerland

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  • Martin D Gebhardt,

    Affiliation: Swiss Federal Office of Public Health, Berne, Switzerland

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  • Zuzana Tomasik,

    Affiliation: University of Zurich, Swiss National Center for Retroviruses, Zurich, Switzerland

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  • Christoph Niederhauser,

    Affiliation: Blood Transfusion Service, Swiss Red Cross Berne, Berne, Switzerland

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  • Sabine Yerly,

    Affiliation: Hopital Cantonal Universitaire, Laboratoire Central de Virologie, Geneva, Switzerland

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  • Philippe Bürgisser,

    Affiliation: Centre Hospitalier Universitaire Vaudois, Service d'Immunologie et d'Allergie, Lausanne, Switzerland

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  • Lukas Matter,

    Affiliation: Institut Dr. Viollier AG, Basel, Switzerland

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  • Meri Gorgievski,

    Affiliation: University of Berne, Institute of Infectious Diseases, Berne, Switzerland

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  • Rolf Dubs,

    Affiliation: University Hospital, Department of Medicine, Zurich, Switzerland

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  • Detlev Schultze,

    Affiliation: Institute for Clinical Microbiology and Immunology, St. Gallen, Switzerland

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  • Ingrid Steffen,

    Affiliation: University of Basel, Institute for Medical Microbiology, Basel, Switzerland

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  • Corinne Andreutti,

    Affiliation: Clinique de la Source, Lausanne, Switzerland

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  • Gladys Martinetti,

    Affiliation: Istituto Cantonale di Microbiologia, Bellinzona, Switzerland

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  • Bruno Güntert,

    Affiliation: Labor Dr. Güntert, Lucerne, Switzerland

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  • Roger Staub,

    Affiliation: Swiss Federal Office of Public Health, Berne, Switzerland

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  • Synove Daneel,

    Affiliation: Kantonsspital St. Gallen, Department of Medicine, St. Gallen, Switzerland

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  • Pietro Vernazza

    Affiliation: Kantonsspital St. Gallen, Department of Medicine, St. Gallen, Switzerland

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  • Published: December 01, 2007
  • DOI: 10.1371/journal.pmed.0040343

About the Authors

Jörg Schüpbach, Zuzana Tomasik
University of Zurich, Swiss National Center for Retroviruses, Zurich, Switzerland
Martin D Gebhardt, Roger Staub
Swiss Federal Office of Public Health, Berne, Switzerland
Christoph Niederhauser
Blood Transfusion Service, Swiss Red Cross Berne, Berne, Switzerland
Sabine Yerly
Hopital Cantonal Universitaire, Laboratoire Central de Virologie, Geneva, Switzerland
Philippe Bürgisser
Centre Hospitalier Universitaire Vaudois, Service d'Immunologie et d'Allergie, Lausanne, Switzerland
Lukas Matter
Institut Dr. Viollier AG, Basel, Switzerland
Meri Gorgievski
University of Berne, Institute of Infectious Diseases, Berne, Switzerland
Rolf Dubs
University Hospital, Department of Medicine, Zurich, Switzerland
Detlev Schultze
Institute for Clinical Microbiology and Immunology, St. Gallen, Switzerland
Ingrid Steffen
University of Basel, Institute for Medical Microbiology, Basel, Switzerland
Corinne Andreutti
Clinique de la Source, Lausanne, Switzerland
Gladys Martinetti
Istituto Cantonale di Microbiologia, Bellinzona, Switzerland
Bruno Güntert
Labor Dr. Güntert, Lucerne, Switzerland
Synove Daneel, Pietro Vernazza
Kantonsspital St. Gallen, Department of Medicine, St. Gallen, Switzerland

Corresponding Author

Email: jorg.schupbach@access.uzh.ch

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

JS, RS, and PV designed the study. JS, MDG, DS, and PV analyzed the data. JS, ZT, CN, SY, PB, LM, MG, RD, DS, IS, CA, BM, and BG enrolled patients. JS, SY, PB, LM, MG, DS, and PV contributed to writing the paper. MDG, ZT, CN, SY, PB, LM, MG, RD, DS, IS, CA, GM, BG, SD, and PV collected data or performed experiments for this study. MDG contributed the clinical data (from surveillance) needed for the analysis. Patients included in the present study are based on patients enrolled in the CHAT study, which included all individuals with a newly diagnosed HIV infection for the duration of 1 year. SD and PV were responsible for the design, data collection, and summary of the CHAT study, of which some results are presented in the present study.