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Research Article

Controlling Endemic Cholera with Oral Vaccines

  • Ira M Longini Jr. mail,

    To whom correspondence should be addressed. E-mail: longini@scharp.org

    Affiliations: Vaccine and Infectious Disease Institute, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America, Department of Biostatistics, School of Public Health and Community Medicine, University of Washington, Seattle, Washington, United States of America

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  • Azhar Nizam,

    Affiliation: Department of Biostatistics, The Rollins School of Public Health, Emory University, Atlanta, Georgia, United States of America

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  • Mohammad Ali,

    Affiliation: International Vaccine Institute, Seoul, Korea

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  • Mohammad Yunus,

    Affiliation: International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka, Bangladesh

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  • Neeta Shenvi,

    Affiliation: Department of Biostatistics, The Rollins School of Public Health, Emory University, Atlanta, Georgia, United States of America

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  • John D Clemens

    Affiliation: International Vaccine Institute, Seoul, Korea

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  • Published: November 27, 2007
  • DOI: 10.1371/journal.pmed.0040336

About the Authors

Ira M Longini Jr.
Vaccine and Infectious Disease Institute, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America
Ira M Longini Jr.
Department of Biostatistics, School of Public Health and Community Medicine, University of Washington, Seattle, Washington, United States of America
Azhar Nizam, Neeta Shenvi
Department of Biostatistics, The Rollins School of Public Health, Emory University, Atlanta, Georgia, United States of America
Mohammad Ali, John D Clemens
International Vaccine Institute, Seoul, Korea
Mohammad Yunus
International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka, Bangladesh

Corresponding Author

Email: longini@scharp.org

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

IML, AN, MA, NS, and JDC designed the study and analyzed the data. All authors contributed to writing the paper. AN developed (i.e., researched, programmed, tested, and implemented) the stochastic simulator of cholera in Matlab (Bangladesh), and analyzed and interpreted the statistical and epidemiological results generated by the simulator. MY was involved as an investigator in the cholera vaccine trial that was conducted in the Matlab field area of the ICDDR,B from 1985 to 1989. NS helped analyze the simulation studies and transformed results into figures. Analysis of the data was based on a trial of cholera vaccines that JDC led in Bangladesh, and on his further analysis of herd protection in the trial data.