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Research Article

N348I in the Connection Domain of HIV-1 Reverse Transcriptase Confers Zidovudine and Nevirapine Resistance

  • Soo-Huey Yap,

    Affiliations: Molecular Interactions Group, Macfarlane Burnet Institute for Medical Research and Public Health, Melbourne, Victoria, Australia, School of Applied Sciences and Engineering, Monash University, Churchill, Victoria, Australia

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  • Chih-Wei Sheen,

    Affiliation: Division of Infectious Diseases, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America

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  • Jonathan Fahey,

    Affiliations: Molecular Interactions Group, Macfarlane Burnet Institute for Medical Research and Public Health, Melbourne, Victoria, Australia, Department of Microbiology, Monash University, Clayton, Victoria, Australia

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  • Mark Zanin,

    Affiliation: Molecular Interactions Group, Macfarlane Burnet Institute for Medical Research and Public Health, Melbourne, Victoria, Australia

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  • David Tyssen,

    Affiliation: Molecular Interactions Group, Macfarlane Burnet Institute for Medical Research and Public Health, Melbourne, Victoria, Australia

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  • Viviane Dias Lima,

    Affiliation: British Columbia Centre for Excellence in HIV/AIDS, Vancouver, British Columbia, Canada

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  • Brian Wynhoven,

    Affiliation: British Columbia Centre for Excellence in HIV/AIDS, Vancouver, British Columbia, Canada

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  • Michael Kuiper,

    Affiliation: Victorian Partnership for Advanced Computing, Carlton South, Victoria, Australia

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  • Nicolas Sluis-Cremer,

    Affiliation: Division of Infectious Diseases, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America

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  • P. Richard Harrigan,

    Affiliation: British Columbia Centre for Excellence in HIV/AIDS, Vancouver, British Columbia, Canada

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  • Gilda Tachedjian mail

    To whom correspondence should be addressed. E-mail: gildat@burnet.edu.au

    Affiliations: Molecular Interactions Group, Macfarlane Burnet Institute for Medical Research and Public Health, Melbourne, Victoria, Australia, Department of Microbiology, Monash University, Clayton, Victoria, Australia, Department of Medicine, Monash University, Melbourne, Victoria, Australia

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  • Published: December 01, 2007
  • DOI: 10.1371/journal.pmed.0040335

About the Authors

Soo-Huey Yap, Jonathan Fahey, Mark Zanin, David Tyssen, Gilda Tachedjian
Molecular Interactions Group, Macfarlane Burnet Institute for Medical Research and Public Health, Melbourne, Victoria, Australia
Soo-Huey Yap
School of Applied Sciences and Engineering, Monash University, Churchill, Victoria, Australia
Chih-Wei Sheen, Nicolas Sluis-Cremer
Division of Infectious Diseases, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America
Jonathan Fahey, Gilda Tachedjian
Department of Microbiology, Monash University, Clayton, Victoria, Australia
Viviane Dias Lima, Brian Wynhoven, P. Richard Harrigan
British Columbia Centre for Excellence in HIV/AIDS, Vancouver, British Columbia, Canada
Michael Kuiper
Victorian Partnership for Advanced Computing, Carlton South, Victoria, Australia
Gilda Tachedjian
Department of Medicine, Monash University, Melbourne, Victoria, Australia

Corresponding Author

Email: gildat@burnet.edu.au

Competing Interests

PRH has received honoraria, research and travel grants and served as a speaker from many pharmaceutical companies, and has served as a consultant to HIV drug resistance testing companies including Virco and Monogram Biosciences. SHY, CWS, JF, MZ, DT, VDL, BW, MK, NSC, and GT declare no competing interests.

Author Contributions

GT, PRH, NSC, and SHY designed the study. PRH and BW gathered the clinical data, and SHY, DT, JF, MZ, and CWS performed the experiments. GT, SHY, PRH, and VDL performed the statistical analyses. MK performed the structural analyses, and GT, NSC, PRH, SHY, and VDL contributed to writing the paper and analysing the data.