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Research Article

Impact of Artemisinin-Based Combination Therapy and Insecticide-Treated Nets on Malaria Burden in Zanzibar

  • Achuyt Bhattarai mail,

    To whom correspondence should be addressed. E-mail: achuyt.bhattarai@ki.se

    Affiliation: Infectious Diseases Unit, Department of Medicine, Karolinska Institutet, Stockholm, Sweden

    X
  • Abdullah S Ali,

    Affiliation: Zanzibar Malaria Control Programme, Zanzibar, Tanzania

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  • S. Patrick Kachur,

    Affiliations: Malaria Branch, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America, Ifakara Health Research and Development Centre, Dar-es-Salaam, Tanzania

    X
  • Andreas Mårtensson,

    Affiliations: Infectious Diseases Unit, Department of Medicine, Karolinska Institutet, Stockholm, Sweden, Emergency Medicine Unit, Department of Medicine, Kullbergska Hospital, Katrineholm, Sweden

    X
  • Ali K Abbas,

    Affiliation: Zanzibar Malaria Control Programme, Zanzibar, Tanzania

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  • Rashid Khatib,

    Affiliation: Ifakara Health Research and Development Centre, Dar-es-Salaam, Tanzania

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  • Abdul-wahiyd Al-mafazy,

    Affiliation: Zanzibar Malaria Control Programme, Zanzibar, Tanzania

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  • Mahdi Ramsan,

    Affiliation: International Development Group, Research Triangle Institute, Zanzibar, Tanzania

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  • Guida Rotllant,

    Affiliation: Infectious Diseases Unit, Department of Medicine, Karolinska Institutet, Stockholm, Sweden

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  • Jan F Gerstenmaier,

    Affiliation: Department of Accident & Emergency, Southern General Hospital, Glasgow, United Kingdom

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  • Fabrizio Molteni,

    Affiliation: Italian Co-operation, Dar-es-Salaam, Tanzania

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  • Salim Abdulla,

    Affiliation: Ifakara Health Research and Development Centre, Dar-es-Salaam, Tanzania

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  • Scott M Montgomery,

    Affiliations: Clinical Epidemiology Unit, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden, Clinical Research Centre, Örebro University Hospital, Örebro, Sweden

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  • Akira Kaneko,

    Affiliation: Infectious Diseases Unit, Department of Medicine, Karolinska Institutet, Stockholm, Sweden

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  • Anders Björkman

    Affiliation: Infectious Diseases Unit, Department of Medicine, Karolinska Institutet, Stockholm, Sweden

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  • Published: November 06, 2007
  • DOI: 10.1371/journal.pmed.0040309

About the Authors

Achuyt Bhattarai, Andreas Mårtensson, Guida Rotllant, Akira Kaneko, Anders Björkman
Infectious Diseases Unit, Department of Medicine, Karolinska Institutet, Stockholm, Sweden
Abdullah S Ali, Ali K Abbas, Abdul-wahiyd Al-mafazy
Zanzibar Malaria Control Programme, Zanzibar, Tanzania
S. Patrick Kachur
Malaria Branch, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America
S. Patrick Kachur, Rashid Khatib, Salim Abdulla
Ifakara Health Research and Development Centre, Dar-es-Salaam, Tanzania
Andreas Mårtensson
Emergency Medicine Unit, Department of Medicine, Kullbergska Hospital, Katrineholm, Sweden
Mahdi Ramsan
International Development Group, Research Triangle Institute, Zanzibar, Tanzania
Jan F Gerstenmaier
Department of Accident & Emergency, Southern General Hospital, Glasgow, United Kingdom
Fabrizio Molteni
Italian Co-operation, Dar-es-Salaam, Tanzania
Scott M Montgomery
Clinical Epidemiology Unit, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden
Scott M Montgomery
Clinical Research Centre, Örebro University Hospital, Örebro, Sweden

Corresponding Author

Email: achuyt.bhattarai@ki.se

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Dr. Bhattarai had full access to the data in the study and takes full responsibility for the integrity of the data and accuracy of the data and its analysis. Study concept and design: Bhattarai, Kachur, Gerstenmaier, Abdulla, and Björkman. Acquisition of data: Bhattarai, Ali, Kachur, Abbas, Al-mafazy, Ramsan, Rotllant, Molteni, and Abdulla. Analysis and interpretation of data: Bhattarai, Kachur, Mårtensson, Montgomery, and Björkman. Drafting of the manuscript: Bhattarai, Kachur, Mårtensson, and Björkman. Statistical analysis: Bhattarai, Kachur, Mårtensson, Montgomery, Kaneko, and Björkman. Obtained funding: Ali, Kachur, Ramsan, and Molteni. Administrative, technical, and material support: Bhattarai, Ali, Kachur, Abbas, Khatib, Al-mafazy, Ramsan, Rotllant, Gerstenmaier, Molteni, and Björkman. Study supervision: Bhattarai, Ali, Kachur, Molteni, Abdulla, and Björkman. Critical revision of the manuscript for important intellectual content: All authors.