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Research Article

Prevention of LPS-Induced Acute Lung Injury in Mice by Mesenchymal Stem Cells Overexpressing Angiopoietin 1

  • Shirley H. J Mei,

    Affiliations: The Terrence Donnelly Research Laboratories, Division of Cardiology, St. Michael's Hospital, University of Toronto, Toronto, Ontario, Canada, Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada

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  • Sarah D McCarter,

    Affiliation: The Terrence Donnelly Research Laboratories, Division of Cardiology, St. Michael's Hospital, University of Toronto, Toronto, Ontario, Canada

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  • Yupu Deng,

    Affiliation: The Terrence Donnelly Research Laboratories, Division of Cardiology, St. Michael's Hospital, University of Toronto, Toronto, Ontario, Canada

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  • Colleen H Parker,

    Affiliation: The Terrence Donnelly Research Laboratories, Division of Cardiology, St. Michael's Hospital, University of Toronto, Toronto, Ontario, Canada

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  • W. Conrad Liles,

    Affiliations: Division of Infectious Diseases, McLaughlin-Rotman Centre for Global Health, Toronto General Research Institute, University of Toronto, Toronto, Ontario, Canada, Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada, Department of Medicine, University of Toronto, Toronto, Ontario, Canada, McLaughlin Centre for Molecular Medicine, University of Toronto, Toronto, Ontario, Canada

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  • Duncan J Stewart mail

    To whom correspondence should be addressed. E-mail: djstewartd@ohri.ca

    Affiliations: The Terrence Donnelly Research Laboratories, Division of Cardiology, St. Michael's Hospital, University of Toronto, Toronto, Ontario, Canada, Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada, Department of Medicine, University of Toronto, Toronto, Ontario, Canada, McLaughlin Centre for Molecular Medicine, University of Toronto, Toronto, Ontario, Canada

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  • Published: September 04, 2007
  • DOI: 10.1371/journal.pmed.0040269

About the Authors

Shirley H. J Mei, Sarah D McCarter, Yupu Deng, Colleen H Parker, Duncan J Stewart
The Terrence Donnelly Research Laboratories, Division of Cardiology, St. Michael's Hospital, University of Toronto, Toronto, Ontario, Canada
W. Conrad Liles
Division of Infectious Diseases, McLaughlin-Rotman Centre for Global Health, Toronto General Research Institute, University of Toronto, Toronto, Ontario, Canada
Shirley H. J Mei, W. Conrad Liles, Duncan J Stewart
Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada
W. Conrad Liles, Duncan J Stewart
Department of Medicine, University of Toronto, Toronto, Ontario, Canada
W. Conrad Liles, Duncan J Stewart
McLaughlin Centre for Molecular Medicine, University of Toronto, Toronto, Ontario, Canada

Corresponding Author

Email: djstewartd@ohri.ca

Competing Interests

This work was supported in part by Northern Therapeutics, for which Duncan J. Stewart serves as its Chief Scientific Officer and has an equity position in the company. There are no other financial conflicts.

Author Contributions

SHJM, SDM and DJS designed the study. SHJM, WCL, and DJS analyzed the data. SHJM, YD, CHP, WCL, and DJS contributed to writing the paper. SHJM, SDM, and YD collected data and performed in vivo experiments for this study. SHJM and SDM established the model together, performed surgeries on mice in tandem, and collected all tissues together. SDM also contributed to some of the very preliminary data analysis. SHJM and CHP were involved in culturing, profiling, labeling, and transfecting the MSCs, and performed ELISAs as well as the confocal microscopy work.