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Research Article

Reducing Amyloid Plaque Burden via Ex Vivo Gene Delivery of an Aβ-Degrading Protease: A Novel Therapeutic Approach to Alzheimer Disease

  • Matthew L Hemming,

    Affiliation: Center for Neurologic Diseases, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America

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  • Michaela Patterson,

    Affiliation: Neuroregeneration Laboratories, McLean Hospital and Harvard University Udall Parkinson's Disease Research Center of Excellence, Belmont, Massachusetts, United States of America

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  • Casper Reske-Nielsen,

    Affiliation: Neuroregeneration Laboratories, McLean Hospital and Harvard University Udall Parkinson's Disease Research Center of Excellence, Belmont, Massachusetts, United States of America

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  • Ling Lin,

    Affiliation: Neuroregeneration Laboratories, McLean Hospital and Harvard University Udall Parkinson's Disease Research Center of Excellence, Belmont, Massachusetts, United States of America

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  • Ole Isacson,

    Affiliation: Neuroregeneration Laboratories, McLean Hospital and Harvard University Udall Parkinson's Disease Research Center of Excellence, Belmont, Massachusetts, United States of America

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  • Dennis J Selkoe mail

    To whom correspondence should be addressed. E-mail: dselkoe@rics.bwh.harvard.edu

    Affiliation: Center for Neurologic Diseases, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America

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  • Published: August 28, 2007
  • DOI: 10.1371/journal.pmed.0040262

About the Authors

Matthew L Hemming, Dennis J Selkoe
Center for Neurologic Diseases, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America
Michaela Patterson, Casper Reske-Nielsen, Ling Lin, Ole Isacson
Neuroregeneration Laboratories, McLean Hospital and Harvard University Udall Parkinson's Disease Research Center of Excellence, Belmont, Massachusetts, United States of America

Corresponding Author

Email: dselkoe@rics.bwh.harvard.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

MLH, OI, and DJS designed the study. MLH, MP, CRN, and LL conducted surgical experiments. MLH collected and analyzed the data. MLH and DJS interpreted the data and drafted the manuscript. All authors have reviewed and approved the manuscript.