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Research Article

Expansion of Regulatory T Cells in Patients with Langerhans Cell Histiocytosis

  • Brigitte Senechal,

    Affiliations: INSERM, U838, Laboratory of Biology of the Mononuclear Phagocyte System, Necker Enfants Malades Institute, Paris, France, Université Paris Descartes Medical School, Paris, France

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  • Gaelle Elain,

    Affiliations: INSERM, U838, Laboratory of Biology of the Mononuclear Phagocyte System, Necker Enfants Malades Institute, Paris, France, Université Paris Descartes Medical School, Paris, France

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  • Eric Jeziorski,

    Affiliations: INSERM, U838, Laboratory of Biology of the Mononuclear Phagocyte System, Necker Enfants Malades Institute, Paris, France, Université Paris Descartes Medical School, Paris, France

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  • Virginie Grondin,

    Affiliations: INSERM, U838, Laboratory of Biology of the Mononuclear Phagocyte System, Necker Enfants Malades Institute, Paris, France, Université Paris Descartes Medical School, Paris, France

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  • Natacha Patey-Mariaud de Serre,

    Affiliations: INSERM, U838, Laboratory of Biology of the Mononuclear Phagocyte System, Necker Enfants Malades Institute, Paris, France, Université Paris Descartes Medical School, Paris, France, Department of Pathology, Hôpital Necker Enfants Malades and Assistance Publique–Hôpitaux de Paris, Paris, France

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  • Francis Jaubert,

    Affiliations: INSERM, U838, Laboratory of Biology of the Mononuclear Phagocyte System, Necker Enfants Malades Institute, Paris, France, Université Paris Descartes Medical School, Paris, France, Department of Pathology, Hôpital Necker Enfants Malades and Assistance Publique–Hôpitaux de Paris, Paris, France

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  • Kheira Beldjord,

    Affiliations: Université Paris Descartes Medical School, Paris, France, Department of Laboratory Medicine, Hôpital Necker Enfants Malades and Assistance Publique–Hôpitaux de Paris, Paris, France

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  • Arielle Lellouch,

    Affiliations: Université Paris Descartes Medical School, Paris, France, Department of Pathology, Hôpital Necker Enfants Malades and Assistance Publique–Hôpitaux de Paris, Paris, France

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  • Christophe Glorion,

    Affiliations: Université Paris Descartes Medical School, Paris, France, Department of Orthopedic Surgery, Hôpital Necker Enfants Malades and Assistance Publique–Hôpitaux de Paris, Paris, France

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  • Michel Zerah,

    Affiliations: Université Paris Descartes Medical School, Paris, France, Department of Neurosurgery, Hôpital Necker Enfants Malades and Assistance Publique–Hôpitaux de Paris, Paris, France

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  • Pierre Mary,

    Affiliation: Department of Orthopedic Surgery, Hôpital d'Enfants Armand Trousseau and Assistance Publique–Hôpitaux de Paris, Paris, France

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  • Mohammed Barkaoui,

    Affiliation: Delegation a la Recherche Clinique, Centre Hospitalier Universitaire de Nantes, Nantes, France

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  • Jean Francois Emile,

    Affiliation: Laboratory of Pathology, Hôpital Ambroise-Paré and Assistance Publique–Hôpitaux de Paris Boulogne Billancourt, France

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  • Liliane Boccon-Gibod,

    Affiliation: Department of Pathology, Assistance Publique–Hôpitaux de Paris, Hôpital d'Enfants Armand Trousseau, Paris, France

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  • Patrice Josset,

    Affiliation: Department of Pathology, Assistance Publique–Hôpitaux de Paris, Hôpital d'Enfants Armand Trousseau, Paris, France

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  • Marianne Debré,

    Affiliation: Immunology and Hematology Unit, Department of Pediatrics, Assistance Publique–Hôpitaux de Paris and Necker Enfants Malades Hospital, Paris, France

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  • Alain Fischer,

    Affiliations: Université Paris Descartes Medical School, Paris, France, Immunology and Hematology Unit, Department of Pediatrics, Assistance Publique–Hôpitaux de Paris and Necker Enfants Malades Hospital, Paris, France

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  • Jean Donadieu,

    Affiliation: Department of Hematology, Assistance Publique–Hôpitaux de Paris and Hôpital d'Enfants Armand Trousseau, Paris, France

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  • Frederic Geissmann mail

    To whom correspondence should be addressed. E-mail: geissman@necker.fr

    Affiliations: INSERM, U838, Laboratory of Biology of the Mononuclear Phagocyte System, Necker Enfants Malades Institute, Paris, France, Université Paris Descartes Medical School, Paris, France, Department of Pathology, Hôpital Necker Enfants Malades and Assistance Publique–Hôpitaux de Paris, Paris, France

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  • Published: August 14, 2007
  • DOI: 10.1371/journal.pmed.0040253

About the Authors

Brigitte Senechal, Gaelle Elain, Eric Jeziorski, Virginie Grondin, Natacha Patey-Mariaud de Serre, Francis Jaubert, Frederic Geissmann
INSERM, U838, Laboratory of Biology of the Mononuclear Phagocyte System, Necker Enfants Malades Institute, Paris, France
Brigitte Senechal, Gaelle Elain, Eric Jeziorski, Virginie Grondin, Natacha Patey-Mariaud de Serre, Francis Jaubert, Kheira Beldjord, Arielle Lellouch, Christophe Glorion, Michel Zerah, Alain Fischer, Frederic Geissmann
Université Paris Descartes Medical School, Paris, France
Natacha Patey-Mariaud de Serre, Francis Jaubert, Arielle Lellouch, Frederic Geissmann
Department of Pathology, Hôpital Necker Enfants Malades and Assistance Publique–Hôpitaux de Paris, Paris, France
Kheira Beldjord
Department of Laboratory Medicine, Hôpital Necker Enfants Malades and Assistance Publique–Hôpitaux de Paris, Paris, France
Christophe Glorion
Department of Orthopedic Surgery, Hôpital Necker Enfants Malades and Assistance Publique–Hôpitaux de Paris, Paris, France
Michel Zerah
Department of Neurosurgery, Hôpital Necker Enfants Malades and Assistance Publique–Hôpitaux de Paris, Paris, France
Pierre Mary
Department of Orthopedic Surgery, Hôpital d'Enfants Armand Trousseau and Assistance Publique–Hôpitaux de Paris, Paris, France
Mohammed Barkaoui
Delegation a la Recherche Clinique, Centre Hospitalier Universitaire de Nantes, Nantes, France
Jean Francois Emile
Laboratory of Pathology, Hôpital Ambroise-Paré and Assistance Publique–Hôpitaux de Paris Boulogne Billancourt, France
Liliane Boccon-Gibod, Patrice Josset
Department of Pathology, Assistance Publique–Hôpitaux de Paris, Hôpital d'Enfants Armand Trousseau, Paris, France
Marianne Debré, Alain Fischer
Immunology and Hematology Unit, Department of Pediatrics, Assistance Publique–Hôpitaux de Paris and Necker Enfants Malades Hospital, Paris, France
Jean Donadieu
Department of Hematology, Assistance Publique–Hôpitaux de Paris and Hôpital d'Enfants Armand Trousseau, Paris, France

Corresponding Author

Email: geissman@necker.fr

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

BS, JD, and FG conceived and wrote the initial study proposal and contributed substantially to conception and design of the research study. GE, EJ, VG, NP, FJ, KB, AL, CG, MZ, PM, JFE, LBG, PJ, and MD made substantial contributions to acquisition of data. BS, MB, JD, and FG performed data analysis and drafted the manuscript. EJ, NP, and AF participated in results interpretation and editing of the manuscript. All authors approved the final version of the manuscript.